Genetic Animal Models of Preconditioning

被引：4
|
作者：
Azad, Priti [1 ]
Haddad, Gabriel G. [1 ,2 ,3 ]
机构：
[1] Univ Calif San Diego, Sect Resp Med, Dept Pediat, San Diego, CA 92093 USA
[2] Univ Calif San Diego, Dept Neurosci, San Diego, CA 92093 USA
[3] Rady Childrens Hosp, San Diego, CA 92123 USA
来源：
TRANSLATIONAL STROKE RESEARCH | 2013年 / 4卷 / 01期
关键词：
Preconditioning; Genetic model; Fruit flies; Hypoxia tolerance; HEAT-SHOCK PROTEINS; RAT-BRAIN SLICES; CEREBRAL-ISCHEMIA; DROSOPHILA-MELANOGASTER; O-2; DEPRIVATION; HYPOXIA-ISCHEMIA; TOLERANCE; ANOXIA; MECHANISMS; EXPRESSION;
D O I：
10.1007/s12975-012-0218-1
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
The preconditioning phenomena have been well established in the heart as well as in the brain. In this review, we detail some of the original studies on preconditioning as well as studies from our lab using rodents and a genetic model system (fruit fly). We have used Drosophila in our lab to solve some of the questions related to tolerance or susceptibility to hypoxia. We believe that these pro-survival strategies and genetic pathways help us understand some of the preconditioning mechanisms that protect the brain from ischemia.
引用
收藏
页码：51 / 55
页数：5
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