Synthesis of L-tryptophan labeled with hydrogen isotopes in the indole ring

被引：8

作者：

Winnicka, E. ^{[1
]}

Kanska, M. ^{[1
]}

机构：

[1] Warsaw Univ, Dept Chem, PL-02089 Warsaw, Poland

来源：

JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY | 2009年 / 279卷 / 02期

关键词：

EOSINOPHILIA-MYALGIA-SYNDROME; PYRIDOXAL-PHOSPHATE; DEUTERIUM; TRITIUM; LYASE; BIOSYNTHESIS; MECHANISM;

D O I：

10.1007/s10967-007-7310-8

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

The isotopomers of L-tryptophan (L-Trp) labeled with hydrogen isotopes in the indole ring were obtained by isotope exchange method. Heavy and tritiated water were used as the sources of stable and radioactive label. Three isotopomers, i.e., [4'-(2)H]-L-Trp, [4'-(3)H]-L-Trp, and doubly labeled [4'-(2)H/(3)H]-L-Trp were synthesized by isotope exchange enhanced by irradiation with a mercury discharge lamp. The indole whole ring labeled isotopomers, i.e., [2',4',5',6',7'-(2)H(5)]-L-, [2',4',5',6',7'-(3)H(5)]-L-, and doubly labeled [2',4',5',6',7'-(2)H/(3)H]-L-Trp were synthesized by isotope exchange between L-Trp and D(2)O or DTO in the presence of deuteriated trifluoroacetic acid.

引用

页码：675 / 678

页数：4

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