Interstrain variation in the human cytomegalovirus DNA polymerase sequence and its effect on genotypic diagnosis of antiviral drug resistance

被引：88
|
作者：
Chou, SW
Lurain, NS
Weinberg, A
Cai, GY
Sharma, PL
Crumpacker, CS
机构：
[1] Vet Adm Med Ctr, Infect Dis Sect P3ID, Portland, OR 97201 USA
[2] Rush Presbyterian St Lukes Med Ctr, Chicago, IL 60612 USA
[3] Univ Colorado, Hlth Sci Ctr, Denver, CO USA
[4] Beth Israel Deaconess Med Ctr, Boston, MA USA
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1999年 / 43卷 / 06期
关键词：
D O I：
10.1128/AAC.43.6.1500
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
The polymerase (pol) coding sequence was determined for 40 independent clinical cytomegalovirus isolates sensitive to ganciclovir and foscarnet. Sequence alignments showed >98% interstrain homology and amino acid variation in only 4% of the 1,237 codons, Almost all variation occurred outside of conserved functional domains where resistance mutations have been identified.
引用
收藏
页码：1500 / 1502
页数：3
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