Cytotoxic Polyhydroxysteroidal Glycosides from Starfish Culcita novaeguineae

被引：13

作者：

Lu, Yunyang ^{[1
]}

Li, Hu ^{[1
,2
]}

Wang, Minchang ^{[3
]}

Liu, Yang ^{[1
]}

Feng, Yingda ^{[1
]}

Liu, Ke ^{[3
]}

Tang, Haifeng ^{[1
]}

机构：

[1] Fourth Mil Med Univ, Sch Pharm, Inst Mat Med, Xian 710032, Shaanxi, Peoples R China

[2] Shanghai Armed Police Corps, Motorized Detachment 1, Shanghai 200126, Peoples R China

[3] Xian Modern Chem Res Inst, Nucl Magnet Resonance Ctr, Xian 710065, Shaanxi, Peoples R China

来源：

MARINE DRUGS | 2018年 / 16卷 / 03期

关键词：

Culcita novaeguineae; starfish; polyhydroxysteroidal glycoside; cytotoxicity; NEURITOGENIC STEROID GLYCOSIDES; LINCKIA-LAEVIGATA; ASTEROSAPONINS; SAPONINS;

D O I：

10.3390/md16030092

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Four new polyhydroxysteroidal glycosides-culcinosides A-D (1, 2, 4, and 7)-along with three known compounds-echinasteroside C (3), linckoside F (5), and linckoside L3 (6)-were isolated from the ethanol extract of starfish Culcita novaeguineae collected from the Xisha Islands of the South China Sea. The structures of new compounds were elucidated through extensive spectroscopic studies and chemical evidence, especially two-dimensional (2D) NMR techniques. The cytotoxicity of the new compounds against human glioblastoma cell lines U87, U251, and SHG44 were evaluated.

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页数：10

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