The caveolae targeting defect of the breast cancer-associated P132L mutant of caveolin-1 can be rescued by co-expression with wild type caveolin-1.

被引:0
|
作者
Han, B. [1 ]
Tiwari, A. [1 ]
Kenworthy, A. K. [1 ]
机构
[1] Vanderbilt Univ, Mol Physiol & Biophys, Nashville, TN 37235 USA
关键词
D O I
暂无
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
P1989
引用
收藏
页数:2
相关论文
共 9 条
  • [1] Lack of caveolin-1 (P132L) somatic mutations in breast cancer
    Ferraldeschi, Roberta
    Latif, Ayse
    Clarke, Robert B.
    Spence, Katherine
    Ashton, Garry
    O'Sullivan, James
    Evans, D. Gareth
    Howell, Anthony
    Newman, William G.
    BREAST CANCER RESEARCH AND TREATMENT, 2012, 132 (03) : 1185 - 1186
  • [2] Lack of caveolin-1 (P132L) somatic mutations in breast cancer
    Roberta Ferraldeschi
    Ayse Latif
    Robert B. Clarke
    Katherine Spence
    Garry Ashton
    James O’Sullivan
    D. Gareth Evans
    Anthony Howell
    William G. Newman
    Breast Cancer Research and Treatment, 2012, 132 : 1185 - 1186
  • [3] Caveolin-1 mutations (P132L and null) and the pathogenesis of breast cancer - Caveolin-1 (P132L) behaves in a dominant-negative manner and Caveolin-1 (-/-) null mice show mammary epithelial cell hyperplasia
    Lee, H
    Park, DS
    Razani, B
    Russell, RG
    Pestell, RG
    Lisanti, MP
    AMERICAN JOURNAL OF PATHOLOGY, 2002, 161 (04): : 1357 - 1369
  • [4] Using Caveolin-1 epithelial immunostaining patterns to stratify human breast cancer patients and predict the Caveolin-1 (P132L) mutation
    Mercier, Isabelle
    Bryant, Kelly G.
    Sotgia, Federica
    Bonuccelli, Gloria
    Witkiewicz, Agnieszka K.
    Dasgupta, Abhijit
    Jasmin, Jean-Francois
    Pestell, Richard G.
    Lisanti, Michael P.
    CELL CYCLE, 2009, 8 (09) : 1396 - 1401
  • [5] Absence of the Caveolin-1 P132L Mutation in Cancers of the Breast and Other Organs
    Koike, Shinya
    Kodera, Yasuhiro
    Nakao, Akimasa
    Iwata, Hiroji
    Yatabe, Yasushi
    JOURNAL OF MOLECULAR DIAGNOSTICS, 2010, 12 (05): : 712 - 717
  • [6] Probing the Caveolin-1 P132L Mutant: Critical Insights into Its Oligomeric Behavior and Structure
    Rieth, Monica D.
    Lee, Jinwoo
    Glover, Kerney Jebrell
    BIOCHEMISTRY, 2012, 51 (18) : 3911 - 3918
  • [7] Clinical and functional significance of loss of caveolin-1 expression in breast cancer-associated fibroblasts
    Simpkins, Samantha A.
    Hanby, Andrew M.
    Holliday, Deborah L.
    Speirs, Valerie
    JOURNAL OF PATHOLOGY, 2012, 227 (04): : 490 - 498
  • [8] Caveolin-1 (P132L), a Common Breast Cancer Mutation, Confers Mammary Cell Invasiveness and Defines a Novel Stem Cell/Metastasis-Associated Gene Signature
    Bonuccelli, Gloria
    Casimiro, Mathew C.
    Sotgia, Federica
    Wang, Chenguang
    Liu, Manran
    Katiyar, Sanjay
    Zhou, Jie
    Dew, Elliott
    Capozza, Franco
    Daumer, Kristin M.
    Minetti, Carlo
    Milliman, Janet N.
    Alpy, Fabien
    Rio, Marie-Christine
    Tomasetto, Catherine
    Mercier, Isabelle
    Flomenberg, Neal
    Frank, Philippe G.
    Pestell, Richard G.
    Lisanti, Michael P.
    AMERICAN JOURNAL OF PATHOLOGY, 2009, 174 (05): : 1650 - 1662
  • [9] Caveolin-1 mutants P132L and Y14F are dominant negative regulators of invasion, migration and aggregation in H1299 lung cancer cells
    Shatz, Maria
    Lustig, Gila
    Reich, Reuven
    Liscovitch, Mordechai
    EXPERIMENTAL CELL RESEARCH, 2010, 316 (10) : 1748 - 1762