Safety and efficacy of splenic artery coil embolization for hypersplenism in liver cirrhosis

被引:27
|
作者
Gu, Jian-Jian [1 ,2 ]
He, Xin-Hong [1 ]
Li, Wen-Tao [1 ]
Ji, Jun [2 ]
Peng, Wei-Jun [1 ]
Li, Guo-Dong [1 ]
Wang, Sheng-Ping [1 ]
Xu, Li-Chao [1 ]
机构
[1] Fudan Univ, Shanghai Canc Ctr, Dept Radiol, Shanghai 200433, Peoples R China
[2] Peoples Hosp Tongzhou Dist, Dept Oncol, Nantong City, Jiangsu, Peoples R China
关键词
Liver cirrhosis; hypersplenism; coil embolization; splenic artery; IDIOPATHIC THROMBOCYTOPENIC PURPURA; ENDOVASCULAR TREATMENT; LAPAROSCOPIC SPLENECTOMY; SURGICAL COMPLICATIONS; TERM; ANEURYSMS; CHILDREN; PSEUDOANEURYSMS; INTERVENTIONS;
D O I
10.1258/ar.2012.110639
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
Background: Partial splenic artery embolization is an effective treatment for hypersplenism but often lacks long-term benefits. Purpose: To evaluate the long-term effects of coil embolization of the splenic artery in patients with liver cirrhosis and hypersplenism. Material and Methods: Forty-nine patients with liver cirrhosis and hypersplenism underwent coil embolization of the main splenic artery. The coils were deployed in the mid- or distal segment of the splenic artery to allow collateral blood flow to the spleen. The following data were collected from 2 weeks to 4 years after the embolization: technical success, length of hospital stay, white blood cell count, platelet count, splenic volume, and complication. Results: The technical success rate of splenic artery coil embolization was 100%. The post embolization syndrome rate was 75% (36/49) with no incidence of major complications. The mean length of hospital stay was 9 days. After embolization, the patient's white blood and platelet counts increased significantly, peaked at 2 weeks, and gradually decreased during the 4-year follow-up period, but remained at significantly higher levels than pre-embolization levels. Follow-up CT scans demonstrated a gradual increase in the volume of the enhanced portions of the spleens with a decrease in the volume of unenhanced portion. No significant changes occurred in the red blood cell count and liver function after the embolization. Conclusion: Embolization of the mid-and distal main splenic artery with coils is a safe and effective treatment of hypersplenism in cirrhosis with long-term hematologic benefits.
引用
收藏
页码:862 / 867
页数:6
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