The Microbeam Insert at the White Beam Beamline P61A at the Synchrotron PETRA III/DESY: A New Tool for High Dose Rate Irradiation Research

被引：2

作者：

Schultke, Elisabeth ^{[1
]}

Fiedler, Stefan ^{[2
]}

Mewes, Catharina ^{[3
]}

Gargioni, Elisabetta ^{[3
]}

Klingenberg, Johannes ^{[4
]}

Faria, Guilherme Abreu ^{[4
]}

Lerch, Michael ^{[5
]}

Petasecca, Marco ^{[5
]}

Prehn, Franziska ^{[1
]}

Wegner, Marie ^{[6
]}

Scholz, Marten ^{[1
]}

Jaekel, Felix ^{[1
]}

Hildebrandt, Guido ^{[1
]}

机构：

[1] Rostock Univ, Dept Radiooncol, Med Ctr, D-18059 Rostock, Germany

[2] European Mol Biol Lab EMBL, Hamburg Outstn, D-22607 Hamburg, Germany

[3] Univ Med Ctr Hamburg Eppendorf, Dept Radiotherapy & Radiooncol, D-20246 Hamburg, Germany

[4] Helmholtz Zentrum HEREON, D-21502 Hamburg, Germany

[5] Univ Wollongong, Ctr Med Radiat Phys, Wollongong, NSW 2522, Australia

[6] Hamburg Univ Technol, Inst Prod Dev & Mech Engn Design, D-21073 Hamburg, Germany

来源：

CANCERS | 2022年 / 14卷 / 20期

关键词：

high dose rate radiotherapy; FLASH radiotherapy; microbeam radiotherapy (MRT); synchrotron; 3-DIMENSIONAL CONFORMAL RADIOTHERAPY; INTENSITY-MODULATED RADIOTHERAPY; RADIATION-THERAPY; BIOCHEMICAL CONTROL; PROSTATE-CANCER; ESCALATION; CARCINOMA; ENERGY; TUMORS;

D O I：

10.3390/cancers14205137

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Simple Summary The excellent preservation of normal tissue function after high dose rate radiotherapy has been shown in pre-clinical studies. Normal tissue in the tumor environment is well preserved even after target doses of several hundred Gy while reliably destroying the tumor cells. These results have triggered the establishment of appropriate research structures at the synchrotron PETRA III on the DESY campus in Hamburg, Germany. Dose rates of hundreds of Gy/s can be achieved, compared to 6-20 Gy/min in clinical radiotherapy. We describe the design, development, key parameters, and first use of a mobile insert for high dose rate radiotherapy research, a new research instrument at P61A, the first polychromatic beamline of PETRA III. The data obtained at the end station P61A will support the international interdisciplinary effort to improve radiotherapy concepts for patients with malignant tumors that are considered radioresistant with the currently established clinical radiotherapy techniques. High dose rate radiotherapies such as FLASH and microbeam radiotherapy (MRT) both have developed to the stage of first veterinary studies within the last decade. With the development of a new research tool for high dose rate radiotherapy at the end station P61A of the synchrotron beamline P61 on the DESY campus in Hamburg, we increased the research capacity in this field to speed up the translation of the radiotherapy techniques which are still experimental, from bench to bedside. At P61, dose rates of several hundred Gy/s can be delivered. Compared to dedicated biomedical beamlines, the beam width available for MRT experiments is a very restrictive factor. We developed two model systems specifically to suit these specific technical parameters and tested them in a first set of experiments.

引用

页数：14