Case of ketoacidosis by a sodium-glucose cotransporter 2 inhibitor in a diabetic patient with a low-carbohydrate diet

被引：82

作者：

Hayami, Tomohide ^{[1
]}

Kato, Yoshiro ^{[1
]}

Kamiya, Hideki ^{[1
]}

Kondo, Masaki ^{[1
]}

Naito, Ena ^{[1
]}

Sugiura, Yukako ^{[1
]}

Kojima, Chika ^{[1
]}

Sato, Sami ^{[1
]}

Yamada, Yuichiro ^{[1
]}

Kasagi, Rina ^{[1
]}

Ando, Toshihito ^{[1
]}

Noda, Saeko ^{[1
]}

Nakai, Hiromi ^{[1
]}

Takada, Eriko ^{[1
]}

Asano, Emi ^{[1
]}

Motegi, Mikio ^{[1
]}

Watarai, Atsuko ^{[2
]}

Kato, Koichi ^{[3
]}

Nakamura, Jiro ^{[1
]}

机构：

[1] Aichi Med Univ, Sch Med, Dept Internal Med, Div Diabet, Nagakute, Aichi 48011, Japan

[2] Chubu Rosai Hosp, Ctr Prevent Med, Nagoya, Aichi, Japan

[3] Aichi Gakuin Univ, Sch Pharm, Lab Med, Nagoya, Aichi 464, Japan

来源：

JOURNAL OF DIABETES INVESTIGATION | 2015年 / 6卷 / 05期

关键词：

Ketoacidosis; Low-carbohydrate diet; Sodium-glucose cotransporter2 inhibitor; INSULIN SENSITIVITY; DAPAGLIFLOZIN;

D O I：

10.1111/jdi.12330

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We present a case of a 32-year-old diabetic woman with Prader-Willi syndrome who developed severe ketoacidosis caused by a sodium-glucose cotransporter2 (SGLT2) inhibitor, a novel class of antihyperglycemic agents, during a strict low-carbohydrate diet. At admission, a serum glucose level of 191mg/dL was relatively low, though laboratory evaluations showed severe ketoacidosis. This is the first report of ketoacidosis caused by a SGLT2 inhibitor. It is necessary to not only pay attention when using a SGLT2 inhibitor in patients following a low-carbohydrate diet, but also to start a low-carbohydrate diet in patients treated with a SGLT2 inhibitor because of a high risk for developing ketoacidosis.

引用

页码：587 / 590

页数：4

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