A new class of DNA alkylating indolino-benzodiazepine agents (BIAs) linked with a DNA binding moiety for use with antibody-drug conjugates (ADCs)

被引：0

作者：

Miller, Michael L. ^{[1
]}

Reid, Emily E. ^{[1
]}

Archer, Katie E. ^{[1
]}

Shizuka, Manami ^{[1
]}

McShea, Molly A. ^{[1
]}

Maloney, Erin K. ^{[1
]}

Ab, Olga ^{[1
]}

Lanieri, Leanne ^{[1
]}

Wilhelm, Alan J. ^{[1
]}

Ponte, Jose F. ^{[1
]}

Yoder, Nicholas C. ^{[1
]}

Chari, Ravi V. ^{[1
]}

机构：

[1] ImmunoGen Inc, Waltham, MA USA

来源：

CANCER RESEARCH | 2018年 / 78卷 / 13期

关键词：

D O I：

10.1158/1538-7445.AM2018-747

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

747

引用

页数：2

共 35 条

[1] Design and synthesis of potent DNA alkylating indolino-benzodiazepine compounds (BIAs) linked with a DNA binding moiety for use in antibody-drug conjugates (ADCs)
Reid, Emily
Archer, Katie
Shizuka, Manami
McShea, Molly
Maloney, Erin
Ab, Olga
Lanieri, Leanne
Wilhelm, Alan
Ponte, Jose
Yoder, Nicholas
Chari, Ravi
Miller, Michael
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2018, 256
[2] Antibody-drug conjugates (ADCs) of indolino-benzodiazepine DNA-alkylating agents
Miller, Michael L.
Shizuka, Manami
Fishkin, Nathan
Reid, Emily
Archer, Katie
Maloney, Erin
Bai, Chen
Ab, Olga
Yoder, Nick C.
Wu, Rui
Hong, Erica
Bogalhas, Megan
Wilhelm, Alan
Whiteman, Kathleen
Chari, Ravi
CANCER RESEARCH, 2015, 75
[3] Peptide-linked indolino-benzodiazepine DNA-alkylating agents for use in antibody-drug conjugates (ADCs)
Shizuka, Manami
Wilhelm, Alan
Archer, Katie
Reid, Emily
Yoder, Nicholas C.
Bai, Chen
Fishkin, Nathan
Harris, Luke
Maloney, Erin
Hong, Erica
Wu, Rui
Ab, Olga
Lai, Kate
Sikka, Surina
Jin, Shan
Pinkas, Jan
Chari, Ravi
Miller, Michael L.
CANCER RESEARCH, 2016, 76
[4] Comparison of site-specific and lysine-linked indolino-benzodiazepine antibody-drug conjugates (ADCs)
Bai, Chen
Yoder, Nicholas C.
Wilhelm, Alan
Adams, Sharlene
Whiteman, Kathleen
Lee, Jenny
O'Callaghan, Katie
Maloney, Erin
Shizuka, Manami
Kovtun, Yelena
Keating, Thomas A.
CANCER RESEARCH, 2017, 77
[5] New class of DNA-alkylating agents with a suitable tolerability profile created for use in antibody-drug conjugates (ADCs).
Miller, Michael
Fishkin, Nathan
Li, Wei
Reid, Emily
Archer, Katie
Maloney, Erin
Kovtun, Yelena
Jones, Gregory
Ellis, Megan
Singh, Rajeeva
Whiteman, Kathleen
Pinkas, Jan
Chari, Ravi
MOLECULAR CANCER THERAPEUTICS, 2013, 12 (11)
[6] Antibody-drug conjugates (ADCs) of peptide-linked Indolino-Benzodiazepine (IGN) DNA-alkylator provides improved anti-tumor activity over that of a crosslinker
Miller, Michael L.
Shizuka, Manami
Ponte, Jose F.
Lanieri, Leanne
Vitharana, Dilrukshi
Qiu, Qifeng
Reid, Emily E.
Archer, Katie E.
Wu, Rui
Maloney, Erin K.
Ab, Olga
Pinkas, Jan
Chari, Ravi V.
CANCER RESEARCH, 2017, 77
[7] Design, synthesis, and evaluation of a novel class of potent DNA-alkylating agents for use in antibody-drug conjugates (ADCs)
Li, Wei
Reid, Emily
Archer, Katie
Fishkin, Nathan
Dandeneau, Andre
Kovtun, Yelena
Harvey, Lauren
Whiteman, Kathy
Miller, Michael L.
Chari, Ravi
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2014, 247
[8] Design, synthesis, and evaluation of a novel class of potent DNA-alkylating agents for use in antibody-drug conjugates (ADCs)
Miller, Michael
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2015, 250
[9] Design, synthesis and evaluation of potent DNA-alkylating agents for use in antibody-drug conjugates (ADCs)
Reid, Emily
Archer, Katie
Bai, Chen
Yoder, Nicholas
Vitharana, Dilrukshi
Lanieri, Leanne
Bogalhas, Megan
Wu, Rui
Qu, Qifeng
Maloney, Erin
Ab, Olga
Ponte, Jose
Chari, Ravi
Miller, Michael
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2017, 254
[10] Design, synthesis, and evaluation of potent DNA-alkylating agents for use in Antibody-Drug Conjugates (ADCs)
Archer, Katie
Reid, Emily
Shizuka, Manami
Wilhelm, Alan
Yoder, Nicholas
Bai, Chen
Fishkin, Nathan
Bogalhas, Megan
Salomon, Paulin
Harris, Luke
Maloney, Erin
Ab, Olga
Chari, Ravi
Miller, Michael
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2017, 253

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