Generic compound isolation using solid-phase trapping as part of the chromatographic purification process. Part 1. Proof of generic trapping concept

被引：3

作者：

Boughtflower, Bob ^{[1
]}

Lane, Steve ^{[1
]}

Mutton, Ian ^{[1
]}

Stasica, Przemyslaw ^{[1
]}

机构：

[1] GlaxoSmithKline, CASS, Analyt Sci, Stevenage SG1 2NY, Herts, England

来源：

JOURNAL OF COMBINATORIAL CHEMISTRY | 2006年 / 8卷 / 04期

关键词：

D O I：

10.1021/cc050147s

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

We present here an alternative, generic approach based on solid-phase trapping that immobilizes the target fraction on a highly retentive hyper-cross-linked PS-DVB "trap" cartridge on-line. This allows further sample washing, processing, and manipulation to enable water and residue-free compound to be accurately quantified using weight. © 2006 American Chemical Society.

引用

页码：441 / 454

页数：14