Efficient Method for the Synthesis of 2,3-Unsubstituted Nitro Containing Indoles from o-Fluoronitroberizenes

被引：16
|
作者：
Liu, Kai
Yin, Dali [1 ]
机构：
[1] Peking Union Med Coll, Inst Mat Med, Dept Med Chem, Beijing 100021, Peoples R China
来源：
ORGANIC LETTERS | 2009年 / 11卷 / 03期
关键词：
SOLUTION-PHASE SYNTHESIS; DIETHYL ACETALS; ANALOGS; CYCLIZATION; INHIBITION;
D O I：
10.1021/ol8027187
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A methodology was developed for the efficient synthesis of 2,3-unsubstituted nitro containing indoles via acid catalyzed intramolecular electrophilic cyclization, Subsequent reduction of nitro groups allows the construction of some indole fused heterocycles and indole quinone diimines. This strategy provides an efficient method for the preparation of biologically and medicinally interesting molecules.
引用
收藏
页码：637 / 639
页数：3
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