Visible-light-induced dearomative oxamination of indole derivatives and dearomative amidation of phenol derivatives

被引：39
|
作者：
Wu, Lingang [1 ]
Hao, Yanan [1 ]
Liu, Yuxiu [1 ]
Song, Haibin [1 ]
Wang, Qingmin [1 ,2 ]
机构：
[1] Nankai Univ, Res Inst Elementoorgan Chem, State Key Lab Elementoorgan Chem, Tianjin 300071, Peoples R China
[2] Collaborat Innovat Ctr Chem Sci & Engn Tianjin, Tianjin 300071, Peoples R China
来源：
CHEMICAL COMMUNICATIONS | 2020年 / 56卷 / 60期
基金：
中国国家自然科学基金;
关键词：
PHOTOREDOX CATALYSIS; MEDIATED DEAROMATIZATION; ASYMMETRIC ALKYLATION; ELECTRON-TRANSFER; NITRENIUM ION; AZIRIDINATION; RADICALS; AZASPIROCYCLIZATION; SULFONAMIDES; REAGENTS;
D O I：
10.1039/d0cc03506h
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Herein, we report a protocol for visible-light-induced dearomative oxamination reactions of indole derivatives to afford functionalized spirocyclic products. These step-economical reactions, which involve C-N and C-O bond formation, feature mild conditions, a broad substrate scope, high yields, exclusive diastereoselectivity and step-economy. In addition, a similar protocol could be used to synthesize spirolactams by dearomative amidation of phenol derivatives.
引用
收藏
页码：8436 / 8439
页数：4
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