Interaction of the δ-aminolevulinic acid dehydratase polymorphism and lead burden on cognitive function:: The VA Normative Aging Study

被引：20
|
作者：
Rajan, Pradeep [1 ]
Kelsey, Karl T. [1 ,2 ,3 ]
Schwartz, Joel D. [1 ,4 ]
Bellinger, David C. [1 ,5 ]
Weuve, Jennifer [1 ]
Spiro, Avron, III [6 ,7 ,8 ]
Sparrow, David [6 ,8 ,9 ]
Smith, Thomas J. [1 ]
Nie, Huiling [1 ,4 ]
Weisskopf, Marc G. [1 ]
Hu, Howard [1 ,4 ,10 ]
Wright, Robert O. [1 ,4 ,11 ]
机构：
[1] Harvard Univ, Sch Publ Hlth, Dept Environm Hlth, Boston, MA 02115 USA
[2] Harvard Univ, Sch Publ Hlth, Dept Genet & Complex Dis, Boston, MA 02115 USA
[3] Brown Univ, Ctr Environm Hlth & Technol, Providence, RI 02912 USA
[4] Harvard Univ, Sch Med, Brigham & Womens Hosp, Dept Med,Channing Lab, Boston, MA 02115 USA
[5] Harvard Univ, Sch Med, Dept Neurol, Childrens Hosp, Boston, MA 02115 USA
[6] Vet Affairs Boston Healthcare Syst, Boston, MA USA
[7] Boston Univ, Dept Hlth Policy & Hlth Servi Res, Goldman Sch Dent Med, Boston, MA 02215 USA
[8] Boston Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02215 USA
[9] Boston Univ, Sch Med, Dept Med, Boston, MA 02215 USA
[10] Univ Michigan, Sch Publ Hlth, Dept Environm Hlth Sci, Ann Arbor, MI 48109 USA
[11] Harvard Univ, Sch Med, Div Emergency Med, Childrens Hosp, Boston, MA 02115 USA
来源：
JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE | 2008年 / 50卷 / 09期
基金：
美国国家卫生研究院;
关键词：
D O I：
10.1097/JOM.0b013e3181792463
中图分类号：
R1 [预防医学、卫生学];
学科分类号：
1004 ; 120402 ;
摘要：
Objective: We evaluated the modifying influence of a delta-aminolvulinic acid dehydratase (ALAD) polymorphism on the relation between lead burden and cognition among older men. Methods: Information on ALAD genotype, lead measurements, Potential confounders, and cognitive testing was collected from 982 participants. For each cognitive test and lead biomarker, we fit separate multiple linear regression models, which included an interaction term for ALAD genotype and the lead biomarker and adjusted for potential confounders. Results: With higher levels of tibia lead, ALAD 1-2/2-2 carriers exhibited worse performance on a spatial copying test in comparison with ALAD 1-1 carriers (P-interaction = 0.03). However, there was no consistent pattern of an ALAD genotype-lead interaction for the other tests. Conclusions: The results provide some evidence that MAD genotype may modify the relation between lead and cognition among older men with low lead burden. However, future work in this area is needed to confirm these suggestive findings.
引用
收藏
页码：1053 / 1061
页数：9
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