Implications of human induced pluripotent stem cells in metabolic disorders: from drug discovery toward precision medicine

被引：13
|
作者：
Cota-Coronado, Agustin [1 ]
Berenice Ramirez-Rodriguez, P. [2 ]
Padilla-Camberosl, Eduardo [1 ]
Diaz, eNstor F. [2 ]
Flores-Fernandez, Jose M. [3 ,4 ]
Avila-Gonzalez, Daniela [1 ,2 ]
Emmanuel Diaz-Martinez, N. [1 ]
机构：
[1] Ctr Invest & Asistencia Tecnol & Diseno Estado Ja, Biotecnol Med & Farmaceut, Guadalajara, Mexico
[2] Inst Nacl Perinatol, Dept Fisiol & Desarrollo Celular, Ciudad De Mexico, Mexico
[3] Univ Alberta, Dept Biochem, 474 Med Sci Bldg, Edmonton, AB T6G 2R3, Canada
[4] Tecnol Estudios Super Villa Guerrero, Div Ingn Ind Alimentarias & Innovac Agr Sustentab, Carretera Toluca Ixtapan Sal,Km 64-5, Villa Guerrero 61763, Estado De Mexic, Mexico
来源：
DRUG DISCOVERY TODAY | 2019年 / 24卷 / 01期
关键词：
INSULIN-PRODUCING CELLS; ENDOTHELIAL-CELLS; GENE CORRECTION; BETA-CELLS; GENERATION; LIVER; ADULT; DIFFERENTIATION; INDUCTION; THERAPY;
D O I：
10.1016/j.drudis.2018.10.001
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Human induced pluripotent stem cells (hiPSCs) enable in vitro high-throughput pharmacological screening assays of diseased tissue. Together with recent genome-wide association studies (GWAS), hiPSCs enable the identification of key mutations for the development of effective treatments based on precise drugs. In concert with CRISPR/Cas9 systems, hiPSC technology can reveal therapeutic targets in metabolic disorders. The ex vivo CRISPR correction of autologous patient-derived hiPSCs has led to the development of replacement cell therapies, providing better patient prognoses.
引用
收藏
页码：334 / 341
页数：8
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