Influence of a high phosphorus intake on serum minerals, bone metabolism and renal function in young adult women

The results of the present study show that there are only few effects of an oral phosphate treatment. The phosphate supplementation was associated with intestinal distress, soft stools or mild diarrhea. The high-phosphorus diet induced no significant changes in serum levels of Ca, PO4 or Zn. Despite mild evaluation of parathyroid hormone, serum levels of 1,25-dihydroxycholecalciferol did not change significantly during the supplementation period, whereas osteocalcin was decreased. Urinary pyridinium crosslinks, pyridinoline and deoxypyridinoline, as specific markers of bone resorption, showed no significant changes during the high phosphorus intake. As indicators of proximal tubular function, urinary microalbumin excretion was lower in the high-phosphorus diet (p>0,05), beta-2-microglobulin remained unchanged and alpha-1-microglobulin level was below the sensitivity of the assay.