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Huazhong Univ Sci & Technol, Coll Life Sci & Technol, Dept Biomed Engn, Hubei Bioinformat & Mol Imaging Key Lab, Wuhan 430074, Hubei, Peoples R China Huazhong Univ Sci & Technol, Coll Life Sci & Technol, Dept Biomed Engn, Hubei Bioinformat & Mol Imaging Key Lab, Wuhan 430074, Hubei, Peoples R China