Topological data analysis (TDA) of U-BIOPRED paediatric peripheral blood gene expression identified asthma phenotypes characterised by alternative splicing of glucocorticoid receptor (GR) mRNA

被引：2

作者：

Schofield, James P. R. ^{[1
]}

Bigler, Jeanette ^{[2
]}

Boedigheimer, Michael ^{[3
]}

Affleck, Karen ^{[4
]}

Taylor, Adam ^{[4
]}

Pavlidis, Stelios ^{[5
]}

Riley, John H. ^{[4
]}

Strazzeri, Fabio ^{[1
]}

Roberts, Graham ^{[1
]}

Brandsma, Joost ^{[1
]}

Bansal, Aruna ^{[6
]}

Nicholas, Ben ^{[1
]}

Xian, Yang ^{[5
]}

Rowe, Anthony ^{[7
]}

Corfield, Julie ^{[8
]}

Wilson, Susan ^{[1
]}

Ward, Jonathan ^{[1
]}

Lutter, Rene ^{[9
]}

Fleming, Louise ^{[5
]}

Shaw, Dominick ^{[10
]}

Per, Bakke ^{[11
]}

Caruso, Massimo ^{[12
]}

Dahlen, Sven-Erik ^{[13
]}

Fowler, Stephen ^{[14
]}

Hashimoto, Simone ^{[15
]}

Horvath, Ildiko ^{[16
]}

Howarth, Peter ^{[1
]}

Krug, Norbert ^{[17
]}

Montuschi, Paolo ^{[18
]}

Sanak, Marek ^{[19
]}

Sandstrom, Thomas ^{[20
]}

Singer, Florian ^{[21
]}

Sun, Kai ^{[5
]}

Pandis, Ioannis ^{[5
]}

Auffray, Charles ^{[22
]}

de Meulder, Bertrand ^{[22
]}

Lefaudeux, Diane ^{[22
]}

Knowles, Richard ^{[23
]}

Fitch, Neil ^{[24
]}

Sousa, Ana ^{[4
]}

Adcock, Ian ^{[5
]}

Chung, Kian Fan ^{[5
]}

Sterk, Peter ^{[25
]}

Skipp, Paul ^{[1
]}

Djukanovic, Ratko ^{[1
]}

机构：

[1] Univ Southampton, Southampton, Hants, England

[2] BJ Grp LLC, Seattle, WA USA

[3] Amgen Inc, Thousand Oaks, CA USA

[4] GSK, Stevenage, Herts, England

[5] Imperial Coll, London, England

[6] Acclarogen, Cambridge, England

[7] Janssen, Cambridge, MA USA

[8] Areteva, Nottingham, England

[9] Univ Amsterdam, Amsterdam, Netherlands

[10] Univ Nottingham, Nottingham, England

[11] Univ Bergen, Bergen, Norway

[12] Univ Catania, Catania, Italy

[13] Karolinska Inst, Stockholm, Sweden

[14] Univ Manchester, Manchester, Lancs, England

[15] Univ Amsterdam, Manchester, Lancs, England

[16] Semmelweis Univ, Budapest, Hungary

[17] Fraunhofer Inst Toxicol & Aerosol Res, Hannover, Germany

[18] Univ Cattolica Sacro Cuore, Milan, Italy

[19] Jagiellonian Univ, Krakow, Poland

[20] Umea Univ, Umea, Sweden

[21] Univ Childrens Hosp Zurich & Bern, Bern, Switzerland

[22] EISBM, Lyon, France

[23] Knowles Consulting, Stevenage, Herts, England

[24] Biosci Consulting, Maasmechelen, Belgium

[25] AMC, Amsterdam, Netherlands

来源：

EUROPEAN RESPIRATORY JOURNAL | 2018年 / 52卷

关键词：

D O I：

10.1183/13993003.congress-2018.PA5435

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

摘要：

PA5435

引用

页数：4

共 3 条

[1] Combined analysis of gene expression and clinical data in the severe asthma U-BIOPRED cohorts
De Meulder, Bertrand
Lefaudeux, Diane
Saqi, Mansoor
Auffray, Charles
Adcock, Ian
Chung, Fan
Bigler, Jeanette
Loza, Matthew
Rao, Navin
Rowe, Anthony
Baribaud, Frederic
Roberts, Graham
Sousa, Ana
Bansal, Aruna
Compton, Chris
Myles, David
Djukanovic, Ratko
Shaw, Dominic
Horvath, Ildiko
Musial, Jacek
Corfield, Julie
Chanez, Pascal
Krug, Norbert
Montuschi, Paolo
Bakke, Per
Sterk, Peter
Polosa, Riccardo
Wager, Scott
Singer, Florian
Fowler, Stephen
Dahlen, Sven -Erik
Sandstrom, Thomas
Higenbottam, Timothy
Nihlen, Ulf
Frey, Urs
Seibold, Wolfgang
EUROPEAN RESPIRATORY JOURNAL, 2014, 44
[2] A Severe Asthma Disease Signature from Gene Expression Profiling of Peripheral Blood from U-BIOPRED Cohorts
Bigler, Jeannette
Boedigheimer, Michael
Schofield, James P. R.
Skipp, Paul J.
Corfield, Julie
Rowe, Anthony
Sousa, Ana R.
Timour, Martin
Twehues, Lori
Hu, Xuguang
Roberts, Graham
Welcher, Andrew A.
Yu, Wen
Lefaudeux, Diane
De Meulder, Bertrand
Auffray, Charles
Chung, Kian F.
Adcock, Ian M.
Sterk, Peter J.
Djukanovic, Ratko
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2017, 195 (10) : 1311 - 1320
[3] Weighted Gene Co-expression Network Analysis of blood paediatric samples from the U-BIOPRED study identifies oxidative stress association with asthma severity
Pavlidis, Stelios
Guo, Yike
Sun, Kai
de Meulder, Bertrand
Riley, John
Affleck, Karen
Taylor, Adam
Schofield, James
Rowe, Anthony
Loza, Matthew
Baribaud, Frederic
Pandis, Ioannis
Sousa, Ana
Corfield, Julie
Knowles, Richard
Djukanovic, Ratko
Auffray, Charles
Sterk, Peter J.
Adcock, Ian
Chung, Fan
Hashimoto, Simone
Fleming, Louise
Roberts, Graham
EUROPEAN RESPIRATORY JOURNAL, 2018, 52

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