A new Ho(III) dinuclear complex: treatment activity and cure values on mania by reducing the expression of the ErbB4 on the noradrenergic neurons

被引:3
|
作者
Chen, Yong-Hua [1 ]
Xu, Yan [1 ]
Wu, Hao [2 ]
Li, Xiao-Yi [3 ]
Zhang, Ming-Jun [1 ]
机构
[1] Zhoushan Second Peoples Hosp, Dept Psychiat, Zhoushan, Zhejiang, Peoples R China
[2] Zhejiang Univ, Sch Med, Sir Run Run Shaw Hosp, Dept Psychiat, Hangzhou, Zhejiang, Peoples R China
[3] Tongde Hosp Zhejiang Prov, Dept Psychiat, Hangzhou, Zhejiang, Peoples R China
关键词
Coordination complex; mania; molecular docking; MOLECULE MAGNET BEHAVIOR; COORDINATION POLYMERS; SERIES;
D O I
10.1080/24701556.2020.1808992
中图分类号
O61 [无机化学];
学科分类号
070301 ; 081704 ;
摘要
The employment of an 8-hydroxyquinoline carbohydrazone tetradentate ligand, 8-hydroxyquinoline-2-carboxaldehyde-(benzoyl)hydrazone (H2L), HoCl3 center dot 6H(2)O and Et3N has led to the formation of dinuclear Ho(III) complex [Ho-2(HL)(2)((PhO)(2)PO2)(4)]center dot 2(CH3OH) (1) in the presence of excess amount of bridging diphenyl phosphate anion, (PhO)(2)PO2-. The biological studies of the title compound were conducted to evaluate the treatment activities on mania. The ELISA detection kit was used to detect the content of the neuroregulin1 (NRG1) in the hippocampus. The RT-PCR was performed to evaluate the relative expression levels of the ErbB4 on the noradrenergic neurons. Furthermore, the mechanism of the complex interacting with the protein is identified by the molecular docking simulation.
引用
收藏
页码:766 / 772
页数:7
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