Toxicity and cosmesis following partial breast irradiation consisting of 40 Gy in 10 daily fractions

被引：6
|
作者：
Trovo, Marco [1 ]
Roncadin, Mario [1 ]
Polesel, Jerry [2 ]
Piccoli, Erica [3 ]
Mileto, Mario [3 ]
Micheli, Elvia [4 ]
Perin, Tiziana [5 ]
Carbone, Antonino [5 ]
Massarut, Samuele [3 ]
Trovo, Mauro G. [1 ]
机构：
[1] Ctr Riferimento Oncol Aviano, Dept Radiat Oncol, I-33081 Aviano, PN, Italy
[2] Ctr Riferimento Oncol Aviano, Dept Epidemiol & Biostat, I-33081 Aviano, PN, Italy
[3] Ctr Riferimento Oncol Aviano, Dept Surg, I-33081 Aviano, PN, Italy
[4] Pordenone Gen Hosp, Dept Surg, Pordenone, Italy
[5] Ctr Riferimento Oncol Aviano, Dept Pathol, I-33081 Aviano, PN, Italy
来源：
BREAST | 2013年 / 22卷 / 05期
关键词：
Breast cancer; Partial breast irradiation; Toxicity; Cosmesis; Hypofractionation; RADIATION-THERAPY; 3D-CRT; CONSERVING THERAPY; DOSE-RATE; LUMPECTOMY CAVITY; CANCER; SURGERY; TRIAL; BRACHYTHERAPY; RADIOTHERAPY; MASTECTOMY;
D O I：
10.1016/j.breast.2012.12.012
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Purpose: To assess the toxicity and cosmetic results in breast cancer patients undergoing adjuvant partial breast irradiation (PBI) to a total dose of 40 Gy in 10 daily fractions (4 Gy/fraction). Methods and materials: Patients affected by early-stage breast cancer were enrolled in this phase II trial. Patients had to be 60 years old and treated with breast conservative surgery for early stage (pT1-T2 pN0-N1a) invasive ductal carcinoma. Results: 77 patients were enrolled. Median follow-up was 18 months. The proposed schedule was well tolerated. One patient reported Grade 3 pain at the site of irradiation. Four (5%) patients experience Grade 2 erythema. Late Grade 2 and 1 fibrosis was observed in 3 (4%) and 14 (18%) patients, respectively. Cosmesis was judged "good/excellent" and "poor" in 75 (97%) and in 2 (3%) patients, respectively. Conclusions: 40 Gy in 10 daily fractions, 4 Gy/fraction, is a well tolerated regimen to deliver PBI. (c) 2013 Elsevier Ltd. All rights reserved.
引用
收藏
页码：744 / 747
页数：4
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