A Polyamine Twist on Hedgehog Signaling

被引：2
|
作者：
Zhao, Xuesong [1 ,2 ]
Sega, Rosalind A. [1 ,2 ]
机构：
[1] Dana Farber Canc Inst, Canc Biol & Pediat Oncol, Boston, MA 02115 USA
[2] Harvard Univ, Sch Med, Neurobiol, Boston, MA 02115 USA
来源：
DEVELOPMENTAL CELL | 2015年 / 35卷 / 01期
关键词：
MEDULLOBLASTOMA; RESISTANCE; TUMORS;
D O I：
10.1016/j.devcel.2015.09.024
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The Hedgehog pathway plays important roles in embryonic development and oncogenesis, but how it affects metabolism is less clear. D'Amico et al. (2015) now demonstrate that the Hedgehog pathway regulates translation of ornithine decarboxylase, thereby enhancing polyamine biosynthesis and cell proliferation in neural precursor cells and in brain tumors.
引用
收藏
页码：1 / 2
页数：2
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