Protective Efficacy of Selenite against Lead-Induced Neurotoxicity in Caenorhabditis elegans

Background: Selenium is an essential micronutrient that has a narrow exposure window between its beneficial and toxic effects. This study investigated the protective potential of selenite (IV) against lead (Pb(II))-induced neurotoxicity in Caenorhabditis elegans. Principal Findings: The results showed that Se(IV) (0.01 mu M) pretreatment ameliorated the decline of locomotion behaviors (frequencies of body bends, head thrashes, and reversal) of C. elegans that are damaged by Pb(II) (100 mu M) exposure. The intracellular ROS level of C. elegans induced by Pb(II) exposure was significantly lowered by Se(IV) supplementation prior to Pb(II) exposure. Finally, Se(IV) protects AFD sensory neurons from Pb(II)-induced toxicity. Conclusions: Our study suggests that Se(IV) has protective activities against Pb(II)-induced neurotoxicity through its antioxidant property.