During the process of Chinese firms' "going-out" into the world market, cross-border M&A, as an important manner of FDI, attracted more and more interests and attention in practice fields and academic fields. As the theoretical reflection of M&A practice, the scholars also do research and analysis to the phenomenon of cross-border M&A, the change of research interests can also reflect the change of hot issues and difficulty in practice. The paper induces the research findings published from 1999 to 2009, uses content analysis method to induce the literature from aspects of time, methodology and research themes, results reveals that the change of research interest takes an inverted U shape, the mainstream methodology is also the theoretical analysis, the research themes also mainly focuses on advantage and disadvantage of cross-border M&A. The paper suggests that empirical method and other methods should be emphasized, the research themes should take various forms in the future.