The Papillomavirus E2 proteins

被引：288
|
作者：
McBride, Alison A. [1 ]
机构：
[1] NIAID, Viral Dis Lab, NIH, Bethesda, MD 20892 USA
来源：
VIROLOGY | 2013年 / 445卷 / 1-2期
关键词：
HPV; Papillomavirus; E2; Replication; Transcription; Tethering; Genomics; Structure; Mutation; DNA-BINDING DOMAIN; COTTONTAIL RABBIT PAPILLOMAVIRUS; CARBOXY-TERMINAL DOMAIN; E1 REPLICATION PROTEIN; BOVINE PAPILLOMAVIRUS; TRANSCRIPTIONAL ACTIVATION; TRANSACTIVATION DOMAIN; CRYSTAL-STRUCTURE; GENE-EXPRESSION; ORIGIN-BINDING;
D O I：
10.1016/j.virol.2013.06.006
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
The papillomavirus E2 proteins are pivotal to the viral life cycle and have well characterized functions in transcriptional regulation, initiation of DNA replication and partitioning the viral genome. The E2 proteins also function in vegetative DNA replication, post-transcriptional processes and possibly packaging. This review describes structural and functional aspects of the E2 proteins and their binding sites on the viral genome. It is intended to be a reference guide to this viral protein. Published by Elsevier Inc.
引用
收藏
页码：57 / 79
页数：23
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