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- [1] Solid-phase synthesis of aza-β3-peptides via Fmoc-strategy and its application in the synthesis of RGD mimeticsPeptides 2004, Proceedings: BRIDGES BETWEEN DISCIPLINES, 2005, : 786 - 787Busnel, OlivierBaudy-Floc'h, Michele ]
Fmoc-aza-β3-Lys-OAllyl and Fmoc-aza-β3-Asp-OAllyl for on-resin head-to-tail cyclization of aza-β3-peptides
被引：1
|作者：
Abbour, Shoukri
[1
]
Baudy-Floc'h, Michele
[1
]
机构：
[1] Univ Rennes 1, ICMV, ISCR, CNRS,UMR 6226, F-35042 Rennes, France
关键词：
Aza-beta(3)-amino acids;
Allyl protection;
Lysine analog;
Aspartique analog;
Cyclic pseudopeptides;
SOLID-PHASE SYNTHESIS;
PROTECTED AZA-BETA(3)-AMINO ACIDS;
ALLOC-AMINO ACIDS;
ALLYLIC PROTECTION;
BETA-PEPTIDE;
DEPROTECTION;
STRATEGY;
RECOGNITION;
DEPSIDES;
CLEAVAGE;
D O I：
10.1016/j.tetlet.2012.11.113
中图分类号：
O62 [有机化学];
学科分类号：
070303 ;
081704 ;
摘要：
A rapid and efficient Fmoc/t-Bu solid-phase peptide synthesis (SPPS) of cyclic aza-beta(3)-peptide analogs by allyl strategy is described. Our synthetic approach includes the synthesis of two new aza-beta(3)-amino acids, Fmoc-aza-beta(3)-Lys-OAllyl and Fmoc-aza-beta(3)-Asp-OAllyl, then the resin attachment of the first aza-beta(3)-amino acid via its side chain, successful use of combination of three orthogonal removable protecting groups, stepwise solid-phase synthesis of linear peptide analog, and on-resin head-to-tail cyclization. (C) 2012 Elsevier Ltd. All rights reserved.
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页码：775 / 778
页数：4
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