Monitoring demyelination and remyelination by magnetization transfer imaging in the mouse brain at 9.4 T

被引：58
|
作者：
Zaaraoui, Wafaa [1 ]
Deloire, Mathilde [2 ]
Merle, Michel [1 ]
Girard, Celine [2 ]
Raffard, Gerard [1 ]
Biran, Marc [1 ]
Inglese, Matilde [3 ]
Petry, Klaus G. [2 ]
Gonen, Oded [3 ]
Brochet, Bruno [2 ]
Franconi, Jean-Michel [1 ]
Dousset, Vincent [2 ]
机构：
[1] Univ Victor Segalen Bordeaux 2, CNRS, UMR5536, F-33076 Bordeaux, France
[2] Univ Victor Segalen Bordeaux 2, Lab Neurobiol Affect Myeline, F-33076 Bordeaux, France
[3] NYU, Sch Med, Dept Radiol, New York, NY 10016 USA
来源：
MAGNETIC RESONANCE MATERIALS IN PHYSICS BIOLOGY AND MEDICINE | 2008年 / 21卷 / 05期
关键词：
demyelination; remyelination; cuprizone; magnetization transfer imaging; magnetization transfer ratio; histology;
D O I：
10.1007/s10334-008-0141-3
中图分类号：
R8 [特种医学]; R445 [影像诊断学];
学科分类号：
1002 ; 100207 ; 1009 ;
摘要：
Objective The aim of this study was to assess quantitatively structural changes in myelin content occurring during demyelination and remyelination by magnetization transfer imaging (MTI). Materials and methods In a reversible model of demyelination with no axonal loss, mice intoxicated by cuprizone were studied by MTI in vivo at 9.4 T. MRI data were compared to histopathological examinations. Results Data revealed that the magnetization transfer ratio (MTR) decreased significantly during demyelination and increased during remyelination with strong correlation to the myelin content (r = 0.79, P = 0.01). Conclusions This study demonstrated that MTR is a sensitive and reproducible quantitative marker to assess myelin loss and repair. This may lead to in vivo monitoring of therapeutic strategies promoting remyelination.
引用
收藏
页码：357 / 362
页数：6
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