Induction of skin sensitization is augmented in Nrf2-deficient mice

被引：15

作者：

van der Veen, Jochem W. ^{[1
,2
]}

Gremmer, Eric R. ^{[2
]}

Vermeulen, Jolanda P. ^{[2
]}

van Loveren, Henk ^{[1
,2
]}

Ezendam, Janine ^{[2
]}

机构：

[1] Maastricht Univ, Dept Toxicogen, NL-6200 MD Maastricht, Netherlands

[2] Natl Inst Publ Hlth & Environm RIVM, Lab Hlth Protect Res GBO, NL-3720 BA Bilthoven, Netherlands

来源：

ARCHIVES OF TOXICOLOGY | 2013年 / 87卷 / 04期

关键词：

Skin sensitization; LLNA; Nrf2-deficient; In vivo; DENDRITIC CELLS; NRF2; EXPRESSION; IMMUNITY; PATHWAY;

D O I：

10.1007/s00204-012-0976-2

中图分类号：

R99 [毒物学（毒理学）];

学科分类号：

100405 ;

摘要：

Several in vitro DNA microarray studies have shown the importance of nuclear factor (erythroid-derived 2)-like 2 (Nrf2) in skin sensitization. Nevertheless, the exact in vivo role of the Nrf2-Keap1 pathway during the induction of skin sensitization remains unknown. To study the function of Nrf2, a local lymph node assay was performed in wild-type and Nrf2-deficient mice using 2,4-dinitrochlorobenzene. The Nrf2-deficient mice show a more pronounced response, indicating that Nrf2 is involved in dampening the induction of skin sensitization.

引用

页码：763 / 766

页数：4

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