Engineering Melanin Nanoparticles as an Efficient Drug-Delivery System for Imaging-Guided Chemotherapy

被引：179

作者：

Zhang, Ruiping ^{[1
,2
,3
]}

Fan, Quli ^{[4
,5
]}

Yang, Min ^{[2
,3
,6
]}

Cheng, Kai ^{[2
,3
]}

Lu, Xiaomei ^{[4
,5
]}

Zhang, Lei ^{[4
,5
]}

Huang, Wei ^{[4
,5
]}

Cheng, Zhen ^{[2
,3
]}

机构：

[1] Shanxi Med Univ, Hosp 1, Dept Radiol, Taiyuan 030001, Peoples R China

[2] Stanford Univ, Sch Med, Mol Imaging Program Stanford, Dept Radiol,Canary Ctr Stanford Canc Early Detect, Stanford, CA 94305 USA

[3] Stanford Univ, Sch Med, Bio X Program, Stanford, CA 94305 USA

[4] Nanjing Univ Posts & Telecommun, Key Lab Organ Elect & Informat Displays, Nanjing 210023, Jiangsu, Peoples R China

[5] Nanjing Univ Posts & Telecommun, Inst Adv Mat, Nanjing 210023, Jiangsu, Peoples R China

[6] Jiangsu Inst Nucl Med, Minist Hlth, Jiangsu Key Lab Mol Nucl Med, Key Lab Nucl Med, Wuxi 214063, Peoples R China

来源：

ADVANCED MATERIALS | 2015年 / 27卷 / 34期

基金：

中国国家自然科学基金;

关键词：

CELL-DERIVED MICROPARTICLES; POLYMERIC NANOPARTICLES; BIOLOGICAL SIGNIFICANCE; COMBINATION THERAPY; QUANTUM DOTS; CANCER; NANOVECTORS; SORAFENIB; MICELLES; BINDING;

D O I：

10.1002/adma.201502201

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

In order to promote imaging-guided chemotherapy for preclinical and clinical applications, endogenous nanosystems with both contrast and drug-delivery properties are highly desired. Here, the simple use of melanin is first reported, and this biopolymer with good biocompatibility and biodegradability, binding ability to drugs and ions, and intrinsic photoacoustic properties, can serve as an efficient endogenous nanosystem for imaging-guided tumor chemotherapy in living mice.

引用

页码：5063 / +

页数：8

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