Use of levonorgestrel as an effective means of contraception in the white-faced saki (Pithecia pithecia)

This study examines the use levonorgestrel (Norplant(R)-2) as a means of contracepting white-faced sakis (Pithecia pithecia). A 70-mg silastic tubule of levonorgestrel was implanted subdermally between the scapulae in four multiparous and two nulliparous females. Implants remained in the females housed with males of proven fertility for 81 to 734 days. All females experienced low, acyclic levels of estrone conjugates (E1C, < 500 ng/mg Cr) and pregnanediol-3-glucuronide (PdG, < 1.5 mug/mg Cr) after insertion of the implant. In five females having nine contraceptive bouts, ovulation was completely blocked for the entire duration of Norplant insertion (range: 81-734 days) as evidenced by a lack of cyclic changes in excretory hormone levels. However, one female was observed to have cyclic ovarian hormonal levels 5.8 months after Norplant insertion. Thus, levonorgestrel can be an effective method for blocking cyclic ovarian hormonal changes for 1 year (n = 2) and possibly as long as 2 years (n = 3). Zoo Biol 21:49-57, 2002. (C) 2002 Wiley-Liss, Inc.