The involvement of human organic anion transporting polypeptides (OATPs) in drug-herb/food interactions

被引:25
|
作者
Ali, Youmna [1 ]
Shams, Tahiatul [1 ]
Wang, Ke [2 ]
Cheng, Zhengqi [1 ]
Li, Yue [1 ]
Shu, Wenying [1 ,3 ]
Bao, Xiaofeng [4 ]
Zhu, Ling [5 ]
Murray, Michael [6 ]
Zhou, Fanfan [1 ]
机构
[1] Univ Sydney, Sydney Pharm Sch, Fac Med & Hlth, Camperdown, NSW 2006, Australia
[2] Jiangsu Inst Nucl Med, Key Lab Nucl Med, Jiangsu Key Lab Mol Nucl Med, Minist Hlth, Wuxi, Jiangsu, Peoples R China
[3] Guangzhou Med Univ, Affiliated Canc Hosp & Inst, Dept Pharm, Guangzhou 511400, Guangdong, Peoples R China
[4] Nantong Univ, Sch Pharm, Nantong 226019, Jiangsu, Peoples R China
[5] Univ Sydney, Save Sight Inst, Sydney, NSW 2000, Australia
[6] Univ Sydney, Fac Med & Hlth, Discipline Pharmacol, Camperdown, NSW 2006, Australia
关键词
Organic anion transporters; Drug-herb interaction; Drug-food interaction; Therapeutic toxicity; MESSENGER-RNA EXPRESSION; SOLUTE CARRIER TRANSPORTERS; GREEN TEA; PLASMA-CONCENTRATIONS; GRAPEFRUIT JUICE; NATURAL-PRODUCTS; CELLULAR UPTAKE; FRUIT JUICES; LIVER; PHARMACOKINETICS;
D O I
10.1186/s13020-020-00351-9
中图分类号
R [医药、卫生];
学科分类号
10 ;
摘要
Organic anion transporting polypeptides (OATPs) are important transporter proteins that are expressed at the plasma membrane of cells, where they mediate the influx of endogenous and exogenous substances including hormones, natural compounds and many clinically important drugs. OATP1A2, OATP2B1, OATP1B1 and OATP1B3 are the most important OATP isoforms and influence the pharmacokinetic performance of drugs. These OATPs are highly expressed in the kidney, intestine and liver, where they determine the distribution of drugs to these tissues. Herbal medicines are increasingly popular for their potential health benefits. Humans are also exposed to many natural compounds in fruits, vegetables and other food sources. In consequence, the consumption of herbal medicines or food sources together with a range of important drugs can result in drug-herb/food interactions via competing specific OATPs. Such interactions may lead to adverse clinical outcomes and unexpected toxicities of drug therapies. This review summarises the drug-herb/food interactions of drugs and chemicals that are present in herbal medicines and/or food in relation to human OATPs. This information can contribute to improving clinical outcomes and avoiding unexpected toxicities of drug therapies in patients.
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页数:10
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