Assessment of Bone Turnover Biomarkers in Lead-Battery Workers with Long-Term Exposure to Lead

被引:8
|
作者
Ravibabu, Kalahasthi [1 ]
Barman, Tapu [2 ]
Bagepally, Bhavani Shankara [3 ]
机构
[1] Indian Council Med Res, Reg Occupat Hlth Ctr Southern, Dept Biochem, ICMR Complex, Bengaluru, Karnataka, India
[2] Natl Inst Cholera & Enter Dis, Dept Bacteriol, Kolkata, W Bengal, India
[3] Natl Inst Epidemiol, Dept NCD, Chennai, Tamil Nadu, India
关键词
Osteocalcin; Tartrate-resistant acid phosphatase; Alkaline phosphatase; Pyridinoline; Lead; Hydroxyproline; Deoxypyridinoline; Bone resorption; OCCUPATIONAL-EXPOSURE; MUSCULOSKELETAL DISORDERS; MINERAL DENSITY; BLOOD-PRESSURE; POPULATION; METABOLISM; OSTEOPOROSIS; ASSOCIATION; HORMONES; INDEXES;
D O I
10.34172/ijoem.2020.1951
中图分类号
R1 [预防医学、卫生学];
学科分类号
1004 ; 120402 ;
摘要
Background: The major portion of lead in the body resides in skeletal system. The bone turnover affects the release of lead into the circulation from bones. The bone turnover biomarkers (BTM) in lead-battery workers with long-term exposure to lead have not been explored yet. Objective: To evaluate the BTM (formation and resorption) in lead-battery workers with long-term exposure to lead in lead-battery manufacturing plant. Methods: 176 male lead-exposed workers and 80 matched comparison group were studied. All participants were examined for blood lead levels (BLLs), bone formation biomarkers-serum osteocalcin (OC), alkaline phosphatase (ALP), bone-specific alkaline phosphatase (BALP)-and bone resorption biomarkers-serum pyridinoline (PYD), deoxypyridinoline (DPYD), tartarate-resistant acid phosphatase-5b (TRACP-5b), and urinary hydroxyproline (UHYP). Results: We found a significantly higher bone formation biomarkers such as BALP (p=0.007) and bone resorption biomarkers, eg, PYD (p=0.048), TRCAP-5b (p=0.001), and UHYP (p=0.001) in lead-exposed workers. A significant (p=0.041) negative correlation (. -0.128) was noted between BLLs and OC. A significant positive correlation was noted between BLLs and TRACP-5b (. 0.176, p=0.005) and UHYP (. 0.258, p=0.004). Serum OC (p=0.040) and UHYP (p=0.015) levels changed significantly with BLL level. Bone resorption biomarkers levels-PYD, TRACP-5b, and BALP-were higher among those with higher BLLs levels. The duration of exposure was significantly associated with BALP (p=0.037), DPYD (p=0.016), TRACP5b (p=0.001), and UHYP (p=0.002) levels. Conclusion: Long-term lead exposure affects the bone turnover.
引用
收藏
页码:140 / 147
页数:8
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