On the biosynthesis of an inhibitor of the p53/MDM2 interaction

被引：15
|
作者：
Duncan, SJ
Williams, DH
Ainsworth, M
Martin, S
Ford, R
Wrigley, SK
机构：
[1] Univ Cambridge, Cambridge Ctr Mol Recognit, Chem Lab, Cambridge CB2 1EW, England
[2] Cubist Pharmaceut UK Ltd, Slough SL1 4EQ, Berks, England
来源：
TETRAHEDRON LETTERS | 2002年 / 43卷 / 06期
基金：
英国医学研究理事会;
关键词：
D O I：
10.1016/S0040-4039(01)02239-0
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The biosynthesis of a fungal secondary metabolite, chlorofusin, which disrupts the interaction between the proteins p53 and MDM2, has been investigated; the acetogenic origin of the chromophore backbone as well as of an aminodecanoic acid residue is demonstrated. (C) 2002 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：1075 / 1078
页数：4
相关论文
共 50 条
  • [1] Binding of an inhibitor of the p53/MDM2 interaction to MDM2
    Duncan, SJ
    Cooper, MA
    Williams, DH
    CHEMICAL COMMUNICATIONS, 2003, (03) : 316 - 317
  • [2] p53 mediated death of cells overexpressing MDM2 by an inhibitor of MDM2 interaction with p53
    Christine Wasylyk
    Roberto Salvi
    Manuela Argentini
    Christine Dureuil
    Isabelle Delumeau
    Joseph Abecassis
    Laurent Debussche
    Bohdan Wasylyk
    Oncogene, 1999, 18 : 1921 - 1934
  • [3] p53 mediated death of cells overexpressing MDM2 by an inhibitor of MDM2 interaction with p53
    Wasylyk, C
    Salvi, R
    Argentini, M
    Dureuil, C
    Delumeau, I
    Abecassis, J
    Debussche, L
    Wasylyk, B
    ONCOGENE, 1999, 18 (11) : 1921 - 1934
  • [4] Fluorescence polarization assay and inhibitor design for MDM2/p53 interaction
    Zhang, RM
    Mayhood, T
    Lipari, P
    Wang, YL
    Durkin, J
    Syto, R
    Gesell, J
    McNemar, C
    Windsor, W
    ANALYTICAL BIOCHEMISTRY, 2004, 331 (01) : 138 - 146
  • [5] P53 α-helix mimetics antagonize p53/MDM2 interaction and activate p53
    Chen, LH
    Yin, H
    Farooqi, B
    Sebti, S
    Hamilton, AD
    Chen, JD
    MOLECULAR CANCER THERAPEUTICS, 2005, 4 (06) : 1019 - 1025
  • [6] Use of a retroinverso p53 peptide as an inhibitor of MDM2
    1600, American Chemical Society, Columbus, United States (126):
  • [7] Use of a retroinverso p53 peptide as an inhibitor of MDM2
    Sakurai, K
    Chung, HS
    Kahne, D
    JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2004, 126 (50) : 16288 - 16289
  • [8] Nanoparticle mediated inhibition of the MDM2:p53 interaction
    Arvizo, Rochelle R.
    Fischer, Nicholas O.
    Jerry, D. Joseph
    Rotello, Vincent M.
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2007, 233
  • [9] P53 Mdm2 Inhibitors
    Khoury, Kareem
    Doemling, Alex
    CURRENT PHARMACEUTICAL DESIGN, 2012, 18 (30) : 4668 - 4678
  • [10] Small molecule inhibitors of p53/MDM2 interaction
    Fotouhi, N
    Graves, B
    CURRENT TOPICS IN MEDICINAL CHEMISTRY, 2005, 5 (02) : 159 - 165
12345