Copper-catalyzed sequential arylation and intramolecular annulation of 2-(2-bromophenyl)-2,3dihydroquinazolin-4(1H)-ones with amidines

被引：13
|
作者：
Duan, Fujun [1 ]
Liu, Miaochang [1 ]
Chen, Jiuxi [1 ]
Ding, Jinchang [1 ]
Hu, Yuefei [1 ,2 ]
Wu, Huayue [1 ]
机构：
[1] Wenzhou Univ, Coll Chem & Mat Engn, Wenzhou 325035, Peoples R China
[2] Tsinghua Univ, Dept Chem, Beijing 100084, Peoples R China
来源：
RSC ADVANCES | 2013年 / 3卷 / 46期
基金：
中国国家自然科学基金;
关键词：
BIOLOGICAL EVALUATION; ARYLBORONIC ACIDS; LUOTONIN-A; QUINAZOLIN-4(3H)-ONES; DERIVATIVES; DESIGN;
D O I：
10.1039/c3ra41969j
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A copper-catalyzed sequential arylation and intramolecular annulation of 2-(2-bromophenyl)-2,3-dihydroquinazolin-4(1H)-ones with alkyl amidines has been developed for the synthesis of 6-alkyl 11bHquinazolino[ 3,4-a] quinazolin-13(12H)-ones (3) in moderate to good yields. However, the arylated products N-(2-(4-oxo-1,2,3,4-tetrahydroquinazolin- 2-yl) phenyl) benzimidamides (4) are isolated when aryl amidines are used in the transformation.
引用
收藏
页码：24001 / 24004
页数：4
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