Discovery, structure-guided design, and validation of WEHI-539, a novel, potent, and selective inhibitor of the pro-survival BCL-2 family member BCL-XL

被引：0
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作者：
Lessene, Guillaume [1 ,2 ]
Czabotar, Peter E. [1 ,2 ]
Sleebs, Brad E. [1 ,2 ]
Zobel, Kerry [3 ]
Lowes, Kym L. [1 ,2 ]
Adams, Jerry M. [1 ,2 ]
Baell, Jonathan B. [1 ,2 ]
Colman, Peter M. [1 ,2 ]
Deshayes, Kurt [3 ]
Fairbrother, Wayne J. [3 ]
Flygare, John A. [3 ]
Gibbons, Paul [3 ]
Kersten, Wilhelmus J. A. [1 ,2 ]
Kulasegaram, Sanji [1 ,2 ]
Moss, Rebecca M. [1 ,2 ]
Parisot, John P. [1 ,2 ]
Smith, Brian J. [1 ,2 ]
Street, Ian P. [1 ,2 ]
Yang, Hong [1 ,2 ]
Huang, David C. S. [1 ,2 ]
Watson, Keith G. [1 ,2 ]
机构：
[1] Walter & Eliza Hall Inst Med Res, Parkville, Vic, Australia
[2] Univ Melbourne, Dept Med Biol, Melbourne, Vic 3010, Australia
[3] Genentech Inc, Redwood City, CA USA
来源：
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY | 2013年 / 245卷
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中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
310-MEDI
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页数：1
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