Structural Properties and Wound Healing Effect of the Sol-Gel Bioactive Glass on Diabetic Skin Wounds

被引：2

作者：

Lin Cai ^{[1
,2
,3
]}

Mao Cong ^{[1
,2
]}

Li Yu-Li ^{[1
,2
]}

Zhang Juan-Juan ^{[1
,2
]}

Miao Guo-Hou ^{[1
,2
]}

Chen Xiao-Feng ^{[1
,2
]}

机构：

[1] Natl Engn Res Ctr Tissue Restorat & Reconstruct, Guangzhou 510006, Guangdong, Peoples R China

[2] S China Univ Technol, Sch Mat Sci & Engn, Guangzhou 510640, Peoples R China

[3] Wenzhou Med Coll, Affiliated Hosp 1, Dept Burns, Wenzhou 325000, Peoples R China

来源：

JOURNAL OF INORGANIC MATERIALS | 2013年 / 28卷 / 01期

关键词：

bioactive glass; Sol-Gel method; wound healing; diabetes; ANGIOGENIC GROWTH-FACTORS; SOFT-TISSUE; BIOLOGY;

D O I：

10.3724/SP.J.1077.2013.12232

中图分类号：

TQ174 [陶瓷工业]; TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

The 45S5 bioactive glass (45S5) was prepared by a melting process, while sol-gel bioactive glass (SGBG) was obtained by Sol-Gel method. The bioactive glasses were characterized by SEM, BET and XRD. Then the wound healing effect was investigated through the wound healing time, wound healing rate and histology examination. The results indicate that the bioactive glass can lessen the wound healing time and increase the healing rates of diabetic rats. Compared with the 45S5, SGBG can promote wound healing of diabetic rats more quickly and efficiently due to the larger surface area and nanostructure. Histological examination shows that bioactive glasses promote the proliferation of fibroblasts and growth of granulation tissue. All results suggest that bioactive glass can accelerate the recovery of skin wounds and SGBG with nanostructure has a better healing effect in diabetes-impaired models.

引用

页码：103 / 108

页数：6

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