Manufacturing mesenchymal stromal cells for phase I clinical trials

被引：41
|
作者：
Hanley, Patrick J. [1 ,2 ]
Mei, Zhuyong [1 ,2 ]
Cabreira-Hansen, Maria da Graca [3 ]
Klis, Mariola [1 ,2 ]
Li, Wei [1 ,2 ]
Zhao, Yali [1 ,2 ]
Durett, April G. [1 ,2 ]
Zheng, Xingwu [4 ]
Wang, Yongping [4 ,5 ]
Gee, Adrian P. [1 ,2 ]
Horwitz, Edwin M. [4 ,5 ]
机构：
[1] Texas Childrens Hosp, Baylor Coll Med, Ctr Cell & Gene Therapy, Houston, TX 77030 USA
[2] Methodist Hosp, Houston, TX 77030 USA
[3] St Lukes Episcopal Hosp, Texas Heart Inst, Houston, TX USA
[4] Childrens Hosp Philadelphia, Philadelphia, PA 19104 USA
[5] Univ Penn, Perelman Sch Med, Philadelphia, PA 19104 USA
来源：
CYTOTHERAPY | 2013年 / 15卷 / 04期
基金：
美国国家卫生研究院;
关键词：
clinical trials; Good Manufacturing Practices; mesenchymal stromal cells; phase I trials; BONE-MARROW; STEM-CELLS; BLOOD; CHILDREN; CULTURE; THERAPY; LIVER;
D O I：
10.1016/j.jcyt.2012.09.007
中图分类号：
Q813 [细胞工程];
学科分类号：
摘要：
Mesenchymal stromal cells (MSCs) are multipotent progenitor cells capable of differentiating into adipocytes, osteoblasts and chondroblasts as well as secreting a vast array of soluble mediators. This potentially makes MSCs important mediators of a variety of therapeutic applications. They are actively under evaluation for immunomodulatory purposes such as graft-versus-host disease and Crohn's disease as well as regenerative applications such as stroke and congestive heart failure. We report our method of generating clinical-grade MSCs together with suggestions gathered from manufacturing experience in our Good Manufacturing Practices facility.
引用
收藏
页码：416 / 422
页数：7
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