Synthesis and antiviral activity of C-3(C-28)-substituted 2,3-seco-triterpenoids

被引：5

作者：

Tolmacheva, I. A. ^{[1
]}

Igosheva, E. V. ^{[1
]}

Savinova, O. V. ^{[2
]}

Boreko, E. I. ^{[2
]}

Grishko, V. V. ^{[1
]}

机构：

[1] Russian Acad Sci, Inst Tech Chem, Ural Branch, Perm 614013, Russia

[2] Minist Hlth Republ Belarus, RSPC Epidemiol & Microbiol, Minsk 220114, BELARUS

来源：

CHEMISTRY OF NATURAL COMPOUNDS | 2014年 / 49卷 / 06期

关键词：

A-seco-triterpenoids; betulin; betulonic acid; allobetulone; beta-amino alcohols; amides; esters; herpes simplex virus type 1 (HSV-1); ANTI-AIDS AGENTS; BIOLOGICAL-ACTIVITY; ACID-DERIVATIVES; BETULINIC ACID; AMIDES; LUPANE;

D O I：

10.1007/s10600-014-0821-3

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Amide conjugates with four structural types of beta-amino alcohols were synthesized from 2,3-seco-18 alpha H-oleananoic and 2,3-seco-lupane C-3(C-28) mono- and dicarboxylic acids. Esters were prepared by reaction of C-3-hydroxy derivatives of A-seco-triterpenoids with dicarboxylic acid anhydrides. The antiviral activity of the synthesized compounds was studied against herpes simplex virus type I. The most active amide was 5a (5.7 mu M, MTC/EC50 32.2).

引用

页码：1050 / 1058

页数：9

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