Overcoming T cell exhaustion by targeting tumor suppressor p53 isoforms as a novel approach to improve T-cell based cancer immunotherapy

被引:0
|
作者
Legscha, K. J. [1 ]
Atunes, E. [1 ]
Amann, E. [1 ,2 ]
Theobald, M. [1 ,2 ,3 ]
Echchannaoui, H. [1 ]
机构
[1] Univ Med, Med Klin 3, Mainz, Germany
[2] German Canc Res Ctr, German Canc Consortium DKTK, Frankfurt, Germany
[3] Res Ctr Immunotherapy FZI, Mainz, Germany
关键词
D O I
暂无
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
V667
引用
收藏
页码:205 / 205
页数:1
相关论文
共 50 条
  • [1] Targeting p53 for adoptive T-cell immunotherapy
    McCarty, TM
    Liu, XP
    Sun, JY
    Peralta, EA
    Diamond, DJ
    Ellenhorn, JDI
    CANCER RESEARCH, 1998, 58 (12) : 2601 - 2605
  • [2] p53 Isoform D133p53a: A Novel Transcriptional Enhancer of T-Cell Effector Function to Improve T-Cell Based Cancer Immunotherapy
    Legscha, Kevin Jan
    Antunes, Edite
    Guezguez, Borhane
    Theobald, Matthias
    Echchannaoui, Hakim
    BLOOD, 2018, 132
  • [3] Overcoming T-cell exhaustion: new therapeutic targets in HCC immunotherapy
    Seimiya, Takahiro
    Otsuka, Motoyuki
    Fujishiro, Mitsuhiro
    HEPATOLOGY, 2023, 78 (04) : 1009 - 1011
  • [4] FREQUENT MUTATIONS IN THE P53 TUMOR SUPPRESSOR GENE IN HUMAN LEUKEMIA T-CELL LINES
    CHENG, J
    HAAS, M
    MOLECULAR AND CELLULAR BIOLOGY, 1990, 10 (10) : 5502 - 5509
  • [5] Modulatory effects of the tumor suppressor p53 in T cell activation and function
    Guo, Gang
    Doan Nguyen
    Zhang, Shu-Zhong
    Huang, Yunping
    Ramsay, Alistair
    Ochoa, Augusto
    Cui, Yan
    JOURNAL OF IMMUNOLOGY, 2012, 188
  • [6] Regulation of cytotoxic T-cell responses by p53 in cancer
    Braun, Mitchell W.
    Iwakuma, Tomoo
    TRANSLATIONAL CANCER RESEARCH, 2016, 5 (06) : 692 - 697
  • [7] ROLE OF THE P53 TUMOR SUPPRESSOR GENE IN THE PATHOGENESIS AND IN THE SUPPRESSION OF ACUTE LYMPHOBLASTIC T-CELL LEUKEMIA
    YEARGIN, J
    CHENG, J
    HAAS, M
    LEUKEMIA, 1992, 6 : S85 - S91
  • [8] Epigenetic regulation of T-cell exhaustion: Implications for cancer immunotherapy
    Youngblood, Benjamin A.
    Ghoniem, Hazem
    Moustaki, Ardiana
    Abdelsamed, Hossam
    Fan, Yiping
    Thomas, Paul
    Stewart, Elizabeth
    Federico, Sara
    CANCER RESEARCH, 2018, 78 (13)
  • [9] Nanoparticle-Based Immunotherapy for Reversing T-Cell Exhaustion
    Li, Fei
    Wang, Yahong
    Chen, Dandan
    Du, Yunjie
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2024, 25 (03)
  • [10] p53 tumor suppressor gene mutations in transformed cutaneous T-cell lymphoma: A study of 12 cases
    Marrogi, AJ
    Khan, MA
    Vonderheid, EC
    Wood, GS
    McBurney, E
    JOURNAL OF CUTANEOUS PATHOLOGY, 1999, 26 (08) : 369 - 378