Sex Differences in the Developmental Origins of Cardiovascular Disease

被引：61

作者：

Intapad, Suttira ^{[1
,3
,4
]}

Ojeda, Norma B. ^{[2
,3
,4
]}

Dasinger, John Henry ^{[1
]}

Alexander, Barbara T. ^{[1
,3
,4
]}

机构：

[1] Univ Mississippi, Med Ctr, Dept Physiol & Biophys, Jackson, MS 39216 USA

[2] Univ Mississippi, Med Ctr, Dept Pediat, Jackson, MS 39216 USA

[3] Univ Mississippi, Med Ctr, Womens Hlth Res Ctr, Jackson, MS 39216 USA

[4] Univ Mississippi, Med Ctr, Ctr Excellence Cardiovasc & Renal Res, Jackson, MS 39216 USA

来源：

PHYSIOLOGY | 2014年 / 29卷 / 02期

关键词：

LOW-BIRTH-WEIGHT; CORONARY-HEART-DISEASE; RENIN-ANGIOTENSIN SYSTEM; MATERNAL PROTEIN RESTRICTION; SYSTOLIC BLOOD-PRESSURE; PRENATALLY PROGRAMMED HYPERTENSION; INTRAUTERINE GROWTH RESTRICTION; RENAL DENERVATION ABOLISHES; SYMPATHETIC-NERVOUS-SYSTEM; META-REGRESSION ANALYSIS;

D O I：

10.1152/physiol.00045.2013

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

The Developmental Origins of Health and Disease (DOHaD) proposes that adverse events during early life program an increased risk for cardiovascular disease. Experimental models provide proof of concept but also indicate that insults during early life program sex differences in adult blood pressure and cardiovascular risk. This review will highlight the potential mechanisms that contribute to the etiology of sex differences in the developmental programming of cardiovascular disease.

引用

页码：122 / 132

页数：11

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