Regioselective C-7 Nitration of 8-Aminoquinoline Amides Using tert-Butyl Nitrite

被引：40

作者：

Mondal, Susmita ^{[1
]}

Samanta, Sadhanendu ^{[1
]}

Hajra, Alakananda ^{[1
]}

机构：

[1] Visva Bharati, Dept Chem, Santini Ketan 731235, W Bengal, India

来源：

ADVANCED SYNTHESIS & CATALYSIS | 2018年 / 360卷 / 05期

关键词：

Regioselctivity; nitration; metal-free; radical; ambient temperature; CATALYZED REMOTE C; H NITRATION; IPSO-NITRATION; COPPER; ACTIVATION; QUINOLINES; FE(NO3)(3)CENTER-DOT-9H(2)O; SULFONYLATION; (BUONO)-BU-T; DERIVATIVES;

D O I：

10.1002/adsc.201701555

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Regioselective C-7 nitration of 8-aminoquinoline amide has been achieved using tert-butyl nitrite under metal-free conditions at ambient temperature. The protocol is applicable to various aryl, heteroaryl as well as aliphatic carboxamides, and exhibits high functional group compatibility. The present method provides selective mononitrated quinoline derivatives. Experimental results suggest that the reaction likely proceeds through a radical pathway.

引用

页码：1026 / 1031

页数：6

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