XIAP inhibitors prime acute leukemia cells for TRAIL- or chemotherapy-induced apoptosis, bypass Bcl-2-imposed resistance and exert antileukemic activity in a NOD/SCID mouse model of pediatric acute leukemia

被引：0
|
作者：
Fakler, Melanie
Loeder, Sandra
Vogler, Meike
Schneider, Katja
Jeremias, Irmela
Debatin, Klaus-Michael
Fulda, Simone
机构：
来源：
MOLECULAR CANCER THERAPEUTICS | 2009年 / 8卷 / 12期
关键词：
D O I：
10.1158/1535-7163JARG-09-PR-8
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
PR-8
引用
收藏
页数：3
相关论文
共 12 条
  • [1] XIAP inhibitors prime childhood acute leukemia cells for TRAIL-induced apoptosis, overcome Bcl-2-mediated resistance and exert anti-leukemic activity in a NOD/SCID mouse model of childhood acute leukemia
    Fakler, Melanie
    Loeder, Sandra
    Vogler, Meike
    Schneider, Katja
    Jeremias, Irmela
    Debatin, Klaus-Michael
    Fuida, Simone
    CANCER RESEARCH, 2009, 69
  • [2] Small molecule XIAP inhibitors sensitize acute leukemia cells for TRAIL- or chemotherapy-induced apoptosis, overcome Bcl-2-mediated resistance and reduce leukemic burden in vivo in NOD/SCID mice
    Fakler, Melanie
    Loder, Sandra
    Vogler, Meike
    Schneider, Katja
    Jeremias, Irnnela
    Debatin, Klaus-Michael
    Fulda, Simone
    CANCER RESEARCH, 2010, 70
  • [3] IAP inhibitors render childhood leukemia cells sensitive for TRAIL- or chemotherapy-triggered apoptosis, overcome resistance by Bcl-2 and exert anti-leukemic activity in a NOD/SCID mouse model in vivo
    Fakler, M.
    Loeder, S.
    Jeremias, I
    Debatin, K-M
    Fulda, S.
    ONKOLOGIE, 2010, 33 : 212 - 212
  • [4] SMALL MOLECULE XIAP INHIBITORS SENSITIZE CHILDHOOD ACUTE LEUKEMIA CELLS FOR DEATH RECEPTOR- OR CHEMOTHERAPY-INDUCED APOPTOSIS IN VITRO AND EXERT ANTI-LEUKEMIC ACTIVITY IN A NOD/SCID MOUSE MODEL IN VIVO
    Fulda, S.
    Loeder, S.
    Fakler, M.
    Schneider, K.
    Jeremias, I.
    Debatin, K. M.
    Fulda, S.
    HAEMATOLOGICA-THE HEMATOLOGY JOURNAL, 2009, 94 : 8 - 8
  • [5] SMALL MOLECULE XIAP INHIBITORS PRIME CHILDHOOD ACUTE LEUKEMIA CELLS FOR TRAIL-INDUCED APOPTOSIS AND OVERCOME BCL-2-MEDIATED RESISTANCE
    Fulda, S.
    Fakler, M.
    Loeder, S.
    Vogler, M.
    Jeremias, I.
    Debatin, K. M.
    HAEMATOLOGICA-THE HEMATOLOGY JOURNAL, 2008, 93 : 374 - 374
  • [6] Small molecule XIAP inhibitors prime childhood acute leukemia cells for TRAIL-induced apoptosis and overcome Bcl-2-mediated resistance
    Fakler, M.
    Vogler, M.
    Jeremias, I
    Debatin, K. M.
    Fulda, S.
    KLINISCHE PADIATRIE, 2008, 220 (02): : 105 - 105
  • [7] Small molecule XIAP inhibitors enhance TRAIL- or anticancer drug-induced apoptosis in childhood acute leukemia cells and overcome Bcl-2-mediated resistance
    Fakler, M.
    Loeder, S.
    Vogler, M.
    Jeremias, I.
    Debatin, K. M.
    Fulda, S.
    EJC SUPPLEMENTS, 2008, 6 (12): : 87 - 87
  • [8] IAP inhibitors prime childhood leukemia cells to chemotherapy-induced apoptosis in a strictly RIP1-dependent manner and exert anti-leukemic activity in a NOD/SCID mouse model in vivo
    Loeder, Sandra
    Fakler, Melanie
    Vanlangenakker, Nele
    Bertrand, Mathieu
    Vandenabeele, Peter
    Jeremias, Irmela
    Debatin, Klaus-Michael
    Fulda, Simone
    CANCER RESEARCH, 2011, 71
  • [9] XIAP Inhibitors Present a Promising New Strategy to Sensitize Childhood Acute Leukemia Cells for Chemotherapy-Induced Apoptosis
    Loeder, Sandra
    Fakler, Melanie
    Jeremias, Irmela
    Debatin, Klaus-Michael
    Fulda, Simone
    BLOOD, 2009, 114 (22) : 1457 - 1457
  • [10] Small Molecule XIAP Inhibitors Cooperate with TRAIL to Trigger Apoptosis in Childhood Acute Leukemia Cells and Overcome Bcl-2-Mediated Resistance
    Fakler, Melanie
    Loeder, Sandra
    Vogler, Meike
    Schneider, Katja
    Jeremias, Irmela
    Debatin, Klaus-Michael
    Fulda, Simone
    BLOOD, 2008, 112 (11) : 317 - 317
12