Prognostic significance of L-type amino-acid transporter 1 expression in surgically resected pancreatic cancer

被引：156

作者：

Kaira, K. ^{[1
,2
]}

Sunose, Y. ^{[3
]}

Arakawa, K. ^{[4
]}

Ogawa, T. ^{[4
]}

Sunaga, N. ^{[1
]}

Shimizu, K. ^{[3
]}

Tominaga, H. ^{[5
]}

Oriuchi, N. ^{[6
]}

Itoh, H. ^{[7
]}

Nagamori, S. ^{[8
]}

Kanai, Y. ^{[8
]}

Segawa, A. ^{[2
]}

Furuya, M. ^{[2
]}

Mori, M. ^{[1
]}

Oyama, T. ^{[2
]}

Takeyoshi, I. ^{[3
]}

机构：

[1] Gunma Univ, Grad Sch Med, Dept Med & Mol Sci, Maebashi, Gunma 3718511, Japan

[2] Gunma Univ, Grad Sch Med, Dept Diagnost Pathol, Maebashi, Gunma 3718511, Japan

[3] Gunma Univ, Grad Sch Med, Dept Thorac & Visceral Organ Surg, Maebashi, Gunma 3718511, Japan

[4] Maebashi Red Cross Hosp, Dept Surg, Maebashi, Gunma, Japan

[5] Gunma Univ, Grad Sch Med, Dept Mol Imaging, Maebashi, Gunma 3718511, Japan

[6] Gunma Univ, Grad Sch Med, Dept Diagnost Radiol & Nucl Med, Maebashi, Gunma 3718511, Japan

[7] Maebashi Red Cross Hosp, Dept Pathol, Maebashi, Gunma, Japan

[8] Osaka Univ, Grad Sch Med, Div Biosyst Pharmacol, Osaka, Japan

来源：

BRITISH JOURNAL OF CANCER | 2012年 / 107卷 / 04期

关键词：

LAT1; CD98; pancreatic cancer; amino-acid transporter; prognostic factor; Ki-67; THYMIC EPITHELIAL TUMORS; LYMPH-NODE METASTASES; CELL LUNG-CANCER; CD98; EXPRESSION; DUCTAL ADENOCARCINOMA; LAT1; CARCINOMA; SURVIVAL; ANGIOGENESIS; MALIGNANCY;

D O I：

10.1038/bjc.2012.310

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

BACKGROUND: The expression of L-type amino-acid transporter 1 (LAT1) is tumour-specific and has been shown to have essential roles in cell growth and survival. However, little is known regarding the clinical significance of LAT1 expression in pancreatic cancer. This study was conducted to determine the prognostic significance of LAT1 expression. METHODS: A total of 97 consecutive patients with surgically resected pathological stage I-IV pancreatic ductal adenocarcinoma were retrospectively reviewed. Tumour sections were stained by immunohistochemistry for LAT1, CD98, Ki-67 and vascular endothelial growth factor (VEGF), and microvessel density was determined by CD34 and p53. RESULTS: L-type amino-acid transporter 1 and CD98 were highly expressed in 52.6% (51/97) and 56.7% (55/97) of cases, respectively (P = 0.568). The expression of LAT1 within pancreatic cancer cells was significantly associated with disease stage, tumour size, Ki-67, VEGF, CD34, p53 and CD98. L-type amino-acid transporter 1 expression was confirmed to be a significant prognostic factor for predicting poor outcome by multivariate analysis. CONCLUSION: L-type amino-acid transporter 1 expression is a promising pathological marker for the prediction of outcome in patients with pancreatic cancer. British Journal of Cancer (2012) 107, 632-638. doi:10.1038/bjc.2012.310 www.bjcancer.com Published online 17 July 2012 (C) 2012 Cancer Research UK

引用

页码：632 / 638

页数：7

共 50 条

[1] Prognostic significance of L-type amino-acid transporter 1 expression in surgically resected pancreatic cancer
K Kaira
Y Sunose
K Arakawa
T Ogawa
N Sunaga
K Shimizu
H Tominaga
N Oriuchi
H Itoh
S Nagamori
Y Kanai
A Segawa
M Furuya
M Mori
T Oyama
I Takeyoshi
British Journal of Cancer, 2012, 107 : 632 - 638
[2] PROGNOSTIC SIGNIFICANCE OF L-TYPE AMINO ACID TRANSPORTER 1 EXPRESSION IN COMPLETELY RESECTED PANCREATIC CANCER
Kaira, K.
Sunose, Y.
Arakawa, K.
Sunaga, N.
Iwasaki, Y.
Mori, M.
Oyama, T.
Takeyoshi, I.
ANNALS OF ONCOLOGY, 2012, 23 : 113 - 113
[3] Prognostic significance of amino-acid transporter expression (LAT1, ASCT2, and xCT) in surgically resected tongue cancer
Toyoda, M.
Kaira, K.
Ohshima, Y.
Ishioka, N. S.
Shino, M.
Sakakura, K.
Takayasu, Y.
Takahashi, K.
Tominaga, H.
Oriuchi, N.
Nagamori, S.
Kanai, Y.
Oyama, T.
Chikamatsu, K.
BRITISH JOURNAL OF CANCER, 2014, 110 (10) : 2506 - 2513
[4] Prognostic significance of amino-acid transporter expression (LAT1, ASCT2, and xCT) in surgically resected tongue cancer
M Toyoda
K Kaira
Y Ohshima
N S Ishioka
M Shino
K Sakakura
Y Takayasu
K Takahashi
H Tominaga
N Oriuchi
S Nagamori
Y Kanai
T Oyama
K Chikamatsu
British Journal of Cancer, 2014, 110 : 2506 - 2513
[5] L-type amino acid transporter 1 expression is a prognostic marker in patients with surgically resected stage I non-small cell lung cancer
Imai, Hisao
Kaira, Kyoichi
Oriuchi, Noboru
Yanagitani, Noriko
Sunaga, Noriaki
Ishizuka, Tamotsu
Kanai, Yoshikatsu
Endou, Hitoshi
Nakajima, Takashi
Mori, Masatomo
HISTOPATHOLOGY, 2009, 54 (07) : 804 - 813
[6] Prognostic significance of L-type amino acid transporter 1 (LAT1) expression in cutaneous melanoma
Shimizu, Akira
Kaira, Kyoichi
Kato, Madoka
Yasuda, Masahito
Takahashi, Ayumi
Tominaga, Hideyuki
Oriuchi, Noboru
Nagamori, Shushi
Kanai, Yoshikatsu
Oyama, Tetsunari
Asao, Takayuki
Ishikawa, Osamu
MELANOMA RESEARCH, 2015, 25 (05) : 399 - 405
[7] L-type Amino Acid Transporter 1 as a Therapeutic Target in Pancreatic Cancer
Norrsell, Ragnar
Bauden, Monika
Andersson, Roland
Ansari, Daniel
CANCER CONTROL, 2024, 31
[8] Prognostic significance of L-type amino acid transporter 1 (LAT1) expression in patients with ovarian tumors
Kaira, Kyoichi
Nakamura, Kazuto
Hirakawa, Takashi
Imai, Hisao
Tominaga, Hideyuki
Oriuchi, Noboru
Nagamori, Shushi
Kanai, Yoshikatsu
Tsukamoto, Norifumi
Oyama, Tetsunari
Asao, Takayuki
Minegishi, Takashi
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH, 2015, 7 (06): : 1161 - 1171
[9] Prognostic significance of L-type amino acid transporter 1 expression in resectable stage I–III nonsmall cell lung cancer
K Kaira
N Oriuchi
H Imai
K Shimizu
N Yanagitani
N Sunaga
T Hisada
S Tanaka
T Ishizuka
Y Kanai
H Endou
T Nakajima
M Mori
British Journal of Cancer, 2008, 98 : 742 - 748
[10] Role of Amino Acid Transporter Expression as a Prognostic Marker in Patients With Surgically Resected Colorectal Cancer
Ogawa, Hiroomi
Kaira, Kyoichi
Motegi, Yoko
Yokobori, Takehiko
Takada, Takahiro
Katoh, Ryuji
Osone, Katsuya
Takahashi, Ryo
Katayama, Chika
Oyama, Tetsunari
Kanai, Yoshikatsu
Yao, Takashi
Asao, Takayuki
Kuwano, Hiroyuki
Shirabe, Ken
ANTICANCER RESEARCH, 2019, 39 (05) : 2535 - 2543

← 1 2 3 4 5 →