Refractive anomalies and visual activation in functional magnetic resonance imaging (fMRI): A versatile and low-cost MR-compatible device to correct a potential confound

被引：6

作者：

Elbel, GK ^{[1
]}

Kaufmann, C ^{[1
]}

Schaefers, S ^{[1
]}

Buser, A ^{[1
]}

Auer, DP ^{[1
]}

机构：

[1] Max Planck Inst Psychiat, NMR Study Grp, D-80804 Munich, Germany

来源：

JOURNAL OF MAGNETIC RESONANCE IMAGING | 2002年 / 15卷 / 01期

关键词：

refractive error; refractive correction; visual stimulation; fMRI; optic blur; myopia; presbyopia;

D O I：

10.1002/jmri.10031

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

Purpose: To develop a magnetic resonance (MR)-compatible, versatile, easy-to-use, and low-cost device for refractive correction. Materials and Methods: We retrospectively evaluated the application and practicability of the refractive correction in 110 subjects who had participated in various functional MR imaging (fMRI) studies with complex visual stimulation paradigms since the introduction of the MR-compatible lens frame at our site. The subjects consisted of 31 patients with Parkinson's disease (age range, 40-85; mean age, 63.2 years) and 79 healthy volunteers (age range, 18-79; mean age, 46.7 years). Results: In volunteers, experimentally induced myopia caused a substantial (>20%) reduction of the blood oxygenation level dependent (BOLD) response to a flickering dartboard. Conclusion: Refractive errors (and the resulting optical blur) may play a nonnegligible role as a possible interfering factor in fMRI experiments with visual stimuli. The MR-compatible frame (fitted with appropriate lenses) used in this study affords full refractive correction at reasonable cost and preparation time.

引用

页码：101 / 107

页数：7