Porous membranes based on poly(ether imide)-graft-poly(vinyl acetate) as a scaffold for cell growth

被引:4
|
作者
Liu, Bin [1 ]
Kuang, Jiangying [2 ]
Shao, Leishan [3 ]
Che, Xinyuan [1 ]
Wang, Fei [1 ]
Wang, Yinghan [1 ]
机构
[1] Sichuan Univ, Coll Polymer Sci & Engn, State Key Lab Polymer Mat Engn, 24 South Sect 1,Yihuan Rd, Chengdu 610065, Sichuan, Peoples R China
[2] Sichuan Univ, State Key Lab Biotherapy, Chengdu, Sichuan, Peoples R China
[3] SINOPEC, Res Inst Maoming Petrochem Co, Maoming, Peoples R China
基金
中国国家自然科学基金;
关键词
Poly(ether imide); vinyl acetate; reversible addition-fragmentation chain transfer; honeycomb-structured porous membrane; cell growth; PHOTOSENSITIVE POLYIMIDE; SURFACE-CHEMISTRY; BREATH FIGURES; IN-VITRO; FILMS; STIMULATION; ELECTRODES; ADHESION; CHLOROMETHYLATION; MICROSIEVES;
D O I
10.1177/0883911517723038
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
A series of poly(ether imide)-graft-poly(vinyl acetate) copolymers with different molecular weights were synthesized successfully and characterized using Fourier transform infrared spectroscopy, ultraviolet-visible spectroscopy, proton nuclear magnetic resonance, gel permeation chromatography, differential scanning calorimeter, thermogravimetric analysis, and X-ray photoelectron spectroscopy analyses. These copolymers were used to fabricate honeycomb-structured porous films using the breath figure templating technique. The surface topology and composition of the highly ordered pattern film were further characterized using a scanning electron microscopy. The results indicated that the poly(ether imide)-graft-poly(vinyl acetate) graft molecular weight ratio influenced the breath figure film surface topology. A model was proposed to elucidate the stabilization process of the poly(ether imide)-graft-poly(vinyl acetate)-aggregated architecture on the water droplet-based templates. In addition, cell viability has been investigated via 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide test, and the cell morphology on the honeycomb-structured poly(ether imide)-graft-poly(vinyl acetate) porous film has been evaluated using a fluorescence microscope. This porous film is shown to be suitable as a matrix for cell growth.
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页码:178 / 194
页数:17
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