Solution phase combinatorial chemistry. Purine- and pyrimidine-based libraries with antibacterial activity via solution phase simultaneous addition of functionalities

被引：4

作者：

Kawasaki, AM ^{[1
]}

Casper, MD ^{[1
]}

Gaus, HJ ^{[1
]}

Herrmann, R ^{[1
]}

Griffey, RH ^{[1
]}

Cook, PD ^{[1
]}

机构：

[1] ISIS Pharmaceut, Carlsbad, CA 92008 USA

来源：

NUCLEOSIDES & NUCLEOTIDES | 1999年 / 18卷 / 4-5期

关键词：

D O I：

10.1080/15257779908041533

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We have effectively used the SPSAF method with purine and pyrimidine based scaffolds to rapidly generate diverse libraries with antibacterial activity. Deconvolution via HPLC fractionation resulted in libraries with reduced complexity (2-10 compounds), a number of which retained good antibacterial activity.

引用

页码：659 / 660

页数：2

共 28 条

[1] Solution phase combinatorial chemistry. Discovery of novel polyazapyridinophanes with potent antibacterial activity by a solution phase simultaneous addition of functionalities approach
An, HY
Cummins, LL
Griffey, RH
Bharadwaj, R
Haly, BD
Fraser, AS
WilsonLingardo, L
Risen, LM
Wyatt, JR
Cook, PD
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1997, 119 (16) : 3696 - 3708
[2] Purine based combinatorial chemistry: Solution phase simultaneous addition of functionalities. Iterative deconvolution by orthogonal protection to a single compound with potent antibacterial activity.
Fraser, AS
Kawasaki, AM
Cook, PD
NUCLEOSIDES & NUCLEOTIDES, 1999, 18 (4-5): : 1087 - 1089
[3] Solution phase combinatorial chemistry. Synthesis of novel linear pyridinopolyamine libraries with potent antibacterial activity
An, HY
Haly, BD
Fraser, AS
Guinosso, CJ
Cook, PD
JOURNAL OF ORGANIC CHEMISTRY, 1997, 62 (15): : 5156 - 5164
[4] Solution phase combinatorial chemistry. Discovery of 13- and 15-membered polyazapyridinocyclophane libraries with antibacterial activity
An, HY
Wang, TM
Mohan, V
Griffey, RH
Cook, PD
TETRAHEDRON, 1998, 54 (16) : 3999 - 4012
[5] Solution phase combinatorial chemistry. Discovery of 13-@ and 15-@membered polyazapyridinocyclophane libraries with antibacterial activity
Tetrahedron, 16 (3999):
[6] Antibacterial activity of tertiary nitrogen based combinatorial libraries prepared by solution phase synthesis
Kung, PP
Lingardo, L
Greig, M
Wyatt, J
Cook, PD
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 1997, 213 : 9 - MEDI
[7] Solution phase combinatorial chemistry. Discovery of potent antimicrobial activity from novel linear pyridinopolyamine libraries.
An, H
Haly, BD
Fraser, AS
Guinosso, CJ
WilsonLingardo, L
Risen, LM
Wyatt, JR
Cook, PD
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 1997, 213 : 7 - MEDI
[8] Solution-phase synthesis of novel linear oxyamine combinatorial libraries with antibacterial activity
Kung, PP
Bharadwaj, R
Fraser, AS
Cook, DR
Kawasaki, AM
Cook, PD
JOURNAL OF ORGANIC CHEMISTRY, 1998, 63 (06): : 1846 - 1852
[9] Synthesis of novel polyazaphane libraries with potent antimicrobial activities by solution phase simultaneous addition of functionalities (SPSAF).
An, H
Cummins, LL
Griffey, RH
Bharadwaj, R
WilsonLingardo, L
Haly, BD
Risen, LM
Wyatt, JR
Cook, PD
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 1997, 213 : 578 - ORGN
[10] Kinetics of benzyl halide reactivity with piperazines by CGE: Solution phase, simultaneous addition of functionality (SFSAF) to prepare combinatorial chemistry libraries
Kung, PP
Gaus, H
Cummins, LL
Greig, M
Cook, PD
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 1996, 212 : 8 - MEDI

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