Non-Enzymatic Modification of Aminophospholipids by Carbonyl-Amine Reactions

被引：24

作者：

Naudi, Alba ^{[1
]}

Jove, Mariona ^{[1
]}

Ayala, Victoria ^{[1
]}

Cabre, Rosanna ^{[1
]}

Portero-Otin, Manuel ^{[1
]}

Pamplona, Reinald ^{[1
]}

机构：

[1] Univ Lleida, Fac Med, Dept Expt Med, Biomed Res Inst Lleida UdL IRBLleida, E-25198 Lleida, Catalonia, Spain

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2013年 / 14卷 / 02期

关键词：

advanced glycation endproducts; advanced lipoxidation endproducts; age-associated diseases; aging; cell membrane; carbonyl compounds; lipid peroxidation; Maillard reaction products; oxidative stress; phosphatidylethanolamine; phosphatidylserine; AMADORI-GLYCATED PHOSPHATIDYLETHANOLAMINE; LOW-DENSITY-LIPOPROTEIN; MEMBRANE LIPID-PEROXIDATION; TANDEM MASS-SPECTROMETRY; RED-BLOOD-CELLS; FATTY-ACID PEROXIDATION; SCHIFF-BASE ADDUCTS; HUMAN-ERYTHROCYTES; END-PRODUCTS; FLUORESCENT PRODUCTS;

D O I：

10.3390/ijms14023285

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Non-enzymatic modification of aminophospholipids by lipid peroxidation-derived aldehydes and reducing sugars through carbonyl-amine reactions are thought to contribute to the age-related deterioration of cellular membranes and to the pathogenesis of diabetic complications. Much evidence demonstrates the modification of aminophospholipids by glycation, glycoxidation and lipoxidation reactions. Therefore, a number of early and advanced Maillard reaction-lipid products have been detected and quantified in different biological membranes. These modifications may be accumulated during aging and diabetes, introducing changes in cell membrane physico-chemical and biological properties.

引用

页码：3285 / 3313

页数：29

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