Circulating miRNA-126,-145 and-155 levels in Mexican women exposed to inorganic arsenic via drinking water

被引：17
|
作者：
Ruiz-Vera, Tania [1 ,2 ]
Ochoa-Martinez, Angeles C. [1 ,2 ]
Zarazua, Sergio [3 ]
Carrizales-Yanez, Leticia [1 ,2 ]
Perez-Maldonado, Ivan N. [1 ,2 ,3 ]
机构：
[1] Univ Autonoma San Luis Potosi, CIACYT, CIAAS, Lab Toxicol Mol, San Luis Potosi, Mexico
[2] Univ Autonoma San Luis Potosi, Fac Med, San Luis Potosi, Mexico
[3] Univ Autonoma San Luis Potosi, Unidad Acad Multidisciplinaria Zona Media, Rio Verde, San Luis Potosi, Mexico
来源：
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY | 2019年 / 67卷
关键词：
Arsenic; Cardiovascular diseases; Epigenetic mechanisms; miR-126; miR-155; Mexico; POLYCYCLIC AROMATIC-HYDROCARBONS; PLASMA ASYMMETRIC DIMETHYLARGININE; PARAOXONASE; POLYMORPHISM; PROTEIN FABP4 LEVELS; CARDIOVASCULAR-DISEASE; MICRORNA BIOMARKERS; EXPRESSION LEVELS; DNA METHYLATION; POTENTIAL ROLE; HEART-DISEASE;
D O I：
10.1016/j.etap.2019.02.004
中图分类号：
X [环境科学、安全科学];
学科分类号：
08 ; 0830 ;
摘要：
The aim of this research was to investigate circulating expression levels of three miRNAs (miR-126, miR-155, and miR-145) proposed as predictive CVD biomarkers in Mexican women exposed to inorganic arsenic via drinking water. Mean UAs concentration of 19.5 +/- 14.0 mu g/g creatinine was found after urine samples were analyzed (n = 105). Significant associations between UAs levels and serum expression levels of miR-155 (p < 0.05) and miR-126 (p < 0.05) were observed after adjustment for assessed co-variables. Alterations in the serum expression levels of miR-155 and miR-126 may be associated with the onset and development of cardiovascular diseases, hence miRNAs could be proposed as prognostic CVD biomarkers. Data found in this study are of concern and risk reduction plans are necessary for the assessed communities to prevent cardiovascular events in this population of women.
引用
收藏
页码：79 / 86
页数：8
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