Obesity in Adults Is Associated With Reduced Lung Function in Metabolic Syndrome and Diabetes The Strong Heart Study

被引:60
|
作者
Yeh, Fawn [1 ]
Dixon, Anne E. [2 ]
Marion, Susan [3 ]
Schaefer, Carl [1 ]
Zhang, Ying [1 ]
Best, Lyle G. [4 ]
Calhoun, Darren [5 ]
Rhoades, Everett R. [1 ]
Lee, Elisa T. [1 ]
机构
[1] Univ Oklahoma, Hlth Sci Ctr, Coll Publ Hlth, Ctr Amer Indian Hlth Res, Oklahoma City, OK 73190 USA
[2] Univ Vermont, Coll Med, Pulm Dis & Crit Care Med Unit, Burlington, VT USA
[3] Univ Delaware, Dept Phys Therapy, Newark, DE USA
[4] Missouri Breaks Ind Res Inc, Timber Lake, SD USA
[5] MedStar Res Inst, Phoenix Field Off, Phoenix, AZ USA
基金
美国国家卫生研究院;
关键词
CARDIOVASCULAR-DISEASE; PULMONARY-FUNCTION; RISK-FACTORS; ATHEROSCLEROSIS RISK; AMERICAN-INDIANS; INFLAMMATION; HEALTH; COMMUNITIES; PREDICTOR;
D O I
10.2337/dc11-0682
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
OBJECTIVE-The purposes of this study were to investigate whether reduced lung function is associated with metabolic syndrome (MS) and diabetes (DM) in American Indians (AIs) and to determine whether lower pulmonary function presents before the development of DM or MS. RESEARCH DESIGN AND METHODS-The Strong Heart Study (SHS) is a multicenter, prospective study of cardiovascular disease (CVD) and its risk factors among AI adults. The present analysis used lung function assessment by standard spirometry at the SHS second examination (1993-1995) in 2,396 adults free of overt lung disease or CVD, with or without DM or MS. Among MS-free/DM-free participants, the development of MS/DM at the SHS third examination (1996-1999) was investigated. RESULTS-Significantly lower pulmonary function was observed for AIs with MS or DM. Impaired pulmonary function was associated with MS and DM after adjustment for age, sex, abdominal obesity, current smoking status, physical activity index, hypertension, and SHS field center. Both forced vital capacity (FVC) and forced expiratory volume in 1 s (FEV1) were negatively associated with insulin resistance or DM severity and with serum markers of inflammation (P < 0.05). FVC and FEV1-to-FVC ratio both predicted DM in unadjusted analyses but not when adjusted for covariates, including waist circumference. In the adjusted model, abdominal obesity predicted both MS and DM. CONCLUSIONS-Reduced lung function is independently associated with MS and with DM, and impaired lung function presents before the development of MS or DM; these associations may result from the effects of obesity and inflammation.
引用
收藏
页码:2306 / 2313
页数:8
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