This is a case report about a 48-year old patient of reproductive age who was referred to our outpatient clinic because of persistent vaginal hemorrhages following a diagnostic D & C due to menometrorrhagia, whose histological examination did not show any pathological findings. During ultrasound testing, the presence of known multiple fibrous nuclei was confirmed, the largest one estimated to occupy the right lateral wall of the uterus and to extend to the adjacent appendage. Surgical treatment of the patient was decided. Intraoperatively, the presence of a solid mass was observed which occupied the entire right fallopian tube, without any participation of the ovary. Abdominal total hysterectomy and bilateral salpingo-oophorectomy was performed. The histological examination of the tissue specimen from the operation confirmed the diagnosis of fallopian tube cancer. The postoperative course was uneventful. Follow - up chemotherapy followed at an oncology center. A year later, the general condition of the patient is good and is monitored systematically by a group of oncologists. This case report attempts a brief review of the diagnostic and therapeutic approach of this rare disease entity, according to the latest scientific data, the timely implementation of which can ensure the best possible prognostic outcome.