Preparation of biodegradable magnetic microspheres with poly(lactic acid)-coated magnetite

被引：86
|
作者：
Zhao, Hong [1 ]
Saatchi, Katayoun [1 ]
Haefeli, Urs O. [1 ]
机构：
[1] Univ British Columbia, Fac Pharmaceut Sci, Vancouver, BC V6T 1Z3, Canada
来源：
JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS | 2009年 / 321卷 / 10期
基金：
加拿大健康研究院; 加拿大自然科学与工程研究理事会;
关键词：
Magnetite; Coating; Stabilization; PLA; PLGA; Poly(lactic acid); Poly (lactide-co-glycolide); Magnetic microspheres; Biodegradability; IRON-OXIDE NANOPARTICLES; BIOMEDICAL APPLICATIONS; FE3O4; NANOPARTICLES; PARTICLES; ADSORPTION; AGENTS; ACIDS;
D O I：
10.1016/j.jmmm.2009.02.038
中图分类号：
T [工业技术];
学科分类号：
08 ;
摘要：
Poly(lactic acid) (PLA)-coated magnetic nanoparticles were made using uncapped PLA with free carboxylate groups. The physical properties of these particles were compared to those of oleate-coated or oleate/sulphonate bilayer (W40) coated magnetic particles. Magnetic microspheres (MMS) with the matrix material poly(lactide-co-glycolide) (PLGA) or PLA were then formed by the emulsion solvent extraction method with encapsulation efficiencies of 40%, 83% and 96% for oleate, PLA and oleate/sulfonate-coated magnetic particles, respectively. MMS made from PLA-coated magnetite were hemocompatible and produced no hemolysis, whereas the other MMS were hemolytic above 0.3mg/mL of blood. (C) 2009 Elsevier B.V. All rights reserved.
引用
收藏
页码：1356 / 1363
页数：8
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