Complex genetic diseases: controversy over the Croesus code

被引：0
|
作者：
Wright, Alan F. [1 ]
Hastie, Nicholas D. [1 ]
机构：
[1] Western Gen Hosp, MRC, Human Genet Unit, Edinburgh EH4 2XU, Midlothian, Scotland
来源：
GENOME BIOLOGY | 2001年 / 2卷 / 08期
关键词：
D O I：
暂无
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
The polarization of views on how best to exploit new information from the Human Genome Project for medicine reflects our ignorance of the genetic architecture underlying common diseases: are susceptibility alleles common or rare, neutral or deleterious, few or many? Single-nucleotide polymorphism (SNP) technology is almost in place to dissect such diseases and to create a personalized medicine, but success is critically dependent on the biology and "Nature to be commanded must be obeyed" (Francis Bacon, 1620, Novum Organum).
引用
收藏
页数：8
相关论文
共 50 条
  • [1] Complex genetic diseases: controversy over the Croesus code
    Alan F Wright
    Nicholas D Hastie
    Genome Biology, 2 (8)
  • [2] Cracking the Monoubiquitin Code of Genetic Diseases
    Sewduth, Raj Nayan
    Baietti, Maria Francesca
    Sablina, Anna A.
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2020, 21 (09)
  • [3] INFECTIOUS DISEASES Controversy over dengue vaccine risk
    Cohen, Jon
    SCIENCE, 2019, 365 (6457) : 961 - 962
  • [4] Perfecting the genetic code with an RNP complex
    Schimmel, Paul
    Yang, Xiang-Lei
    STRUCTURE, 2006, 14 (12) : 1729 - 1730
  • [5] Deciphering the Genetic Code of Autoimmune Kidney Diseases
    Huang, Stephanie U-Shane
    Kulatunge, Oneli
    O'Sullivan, Kim Maree
    GENES, 2023, 14 (05)
  • [6] Genetic dissection of complex diseases
    Campion, D
    M S-MEDECINE SCIENCES, 2001, 17 (11): : 1139 - 1148
  • [7] Genetic analysis of complex diseases
    Scott, WK
    PericakVance, MA
    Haines, JL
    SCIENCE, 1997, 275 (5304) : 1327 - 1327
  • [8] The Torah code controversy
    Haralick, RM
    FOURTEENTH INTERNATIONAL CONFERENCE ON PATTERN RECOGNITION, VOLS 1 AND 2, 1998, : 1779 - 1783
  • [9] Genetic code expansion for multiprotein complex engineering
    Christine Koehler
    Paul F Sauter
    Mirella Wawryszyn
    Gemma Estrada Girona
    Kapil Gupta
    Jonathan J M Landry
    Markus Hsi-Yang Fritz
    Ksenija Radic
    Jan-Erik Hoffmann
    Zhuo A Chen
    Juan Zou
    Piau Siong Tan
    Bence Galik
    Sini Junttila
    Peggy Stolt-Bergner
    Giancarlo Pruneri
    Attila Gyenesei
    Carsten Schultz
    Moritz Bosse Biskup
    Hueseyin Besir
    Vladimir Benes
    Juri Rappsilber
    Martin Jechlinger
    Jan O Korbel
    Imre Berger
    Stefan Braese
    Edward A Lemke
    Nature Methods, 2016, 13 : 997 - 1000
  • [10] Genetic code expansion for multiprotein complex engineering
    Koehler, Christine
    Sauter, Paul F.
    Wawryszyn, Mirella
    Girona, Gemma Estrada
    Gupta, Kapil
    Landry, Jonathan J. M.
    Fritz, Markus Hsi-Yang
    Radic, Ksenija
    Hoffmann, Jan-Erik
    Chen, Zhuo A.
    Zou, Juan
    Tan, Piau Siong
    Galik, Bence
    Junttila, Sini
    Stolt-Bergner, Peggy
    Pruneri, Giancarlo
    Gyenesei, Attila
    Schultz, Carsten
    Biskup, Moritz Bosse
    Besir, Hueseyin
    Benes, Vladimir
    Rappsilber, Juri
    Jechlinger, Martin
    Korbel, Jan O.
    Berger, Imre
    Braese, Stefan
    Lemke, Edward A.
    NATURE METHODS, 2016, 13 (12) : 997 - +
12345